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首页> 外文期刊>Clinical and laboratory haematology >Delayed haemolytic transfusion reaction caused by anti-M antibody in a patient receiving interleukin-2 and interferon for metastatic renal cell cancer.
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Delayed haemolytic transfusion reaction caused by anti-M antibody in a patient receiving interleukin-2 and interferon for metastatic renal cell cancer.

机译：在接受白介素2和干扰素治疗的转移性肾细胞癌患者中，抗M抗体引起的溶血性输血反应延迟。

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摘要

Anti-M is usually a naturally occurring cold-reactive immunoglobulin M (IgM) antibody, often with an immunoglobulin G (IgG) component, and is seldom implicated in delayed haemolytic transfusion reactions (DHTR). However, cases have been reported. In the majority, a DHTR is not suspected until further blood is requested and a new antibody is detected on pretransfusion testing. We describe the case of a young man receiving therapy with interleukin-2 (IL-2) and interferon-alpha (IFN-alpha) for metastatic renal cell cancer who developed a clinically suspected DHTR that was confirmed serologically to be caused by anti-M, reactive at 37 degrees C. We discuss the possible role of his biochemotherapy in the development of the DHTR.
机译：抗-M通常是天然存在的冷反应性免疫球蛋白M（IgM）抗体，通常带有免疫球蛋白G（IgG）成分，很少涉及延迟溶血性输血反应（DHTR）。但是，已经有病例报告。在大多数情况下，直到需要更多血液并在输血前测试中检测到新抗体时才怀疑DHTR。我们描述了一个年轻人接受白细胞介素2（IL-2）和干扰素-α（IFN-α）治疗转移性肾细胞癌的案例，该患者发展出临床怀疑的DHTR，经血清学证实是由抗M引起的，在37度有反应。我们讨论了他的生物化学疗法在DHTR发育中的可能作用。

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