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首页> 外文期刊>Clinical and laboratory haematology >Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin.
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Three different chromogenic methods do not give equivalent anti-Xa levels for patients on therapeutic low molecular weight heparin (dalteparin) or unfractionated heparin.

机译：对于使用治疗性低分子量肝素（达肝素）或普通肝素的患者，三种不同的生色方法不能提供相同的抗Xa水平。

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摘要

In this study we compare three chromogenic methods (IL-Heparin, Stachrom Heparin and Heparin Sigma) on two different instruments (ACL300+ and AMAX CS190) for patients on dalteparin (n = 41), a low molecular weight heparin or unfractionated heparin (n = 50). For dalteparin the mean anti-Xa levels for IL-Heparin, Stachrom Heparin and Heparin Sigma were 0.27, 0.30 and 0.21 U/ml, respectively, while for heparin they were 0.52, 0.55 and 0.41 U/ml, respectively. To test for instrument specific effects, IL-Heparin and Stachrom Heparin were repeated on both instruments on 42 patients receiving unfractionated heparin. For IL-Heparin the mean anti-Xa levels on the AMAX CS190 and ACL300+ were 0.51 and 0.59 U/ml, respectively, while for Stachrom Heparin they were 0.55 and 0.67 anti-Xa U/ml. We conclude that different chromogenic anti-Xa methods do not give equivalent anti-Xa levels for the same samples. Moreover, the differences are clinically significant. This is not explained entirely by instrumentation effects. Recommended therapeutic ranges may need to be method and instrument specific.
机译：在这项研究中，我们比较了两种不同仪器（ACL300 +和AMAX CS190）上使用达肝素（n = 41），低分子量肝素或普通肝素（n = 3）的三种生色方法（IL-肝素，Stachrom肝素和肝素Sigma）。 50）。对于达肝素，IL-肝素，Stachrom肝素和肝素Sigma的平均抗Xa水平分别为0.27、0.30和0.21 U / ml，而对于肝素，它们分别为0.52、0.55和0.41 U / ml。为了测试仪器的特定效果，对42例接受普通肝素治疗的患者在两种仪器上均重复使用了IL-肝素和Stachrom肝素。对于IL-肝素，AMAX CS190和ACL300 +的平均抗Xa水平分别为0.51和0.59 U / ml，而对于Stachrom肝素，抗Xa水平分别为0.55和0.67抗Xa U / ml。我们得出的结论是，对于相同的样品，不同的生色抗Xa方法不能提供等效的抗Xa水平。而且，这些差异在临床上是重要的。仪器效果并不能完全解释这一点。推荐的治疗范围可能需要特定于方法和仪器。

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