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首页> 外文期刊>Clinical and laboratory haematology >Waveform analysis of clotting test optical profiles in the diagnosis and management of disseminated intravascular coagulation (DIC).
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Waveform analysis of clotting test optical profiles in the diagnosis and management of disseminated intravascular coagulation (DIC).

机译：凝血测试光学曲线的波形分析在弥散性血管内凝血（DIC）的诊断和管理中的作用。

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摘要

Transmittance waveform charts the changes in light transmittance on standard coagulation assays, such as the prothrombin time (PT) and activated partial thromboplastin time (APTT). Analysis and characterization of these data on photo-optical coagulation analysers provides additional qualitative and quantitative information to that obtained using the clotting time alone. The most thoroughly evaluated clinical application is that of the biphasic APTT waveform with disseminated intravascular coagulation (DIC). The degree of waveform abnormality correlates directly with the severity of haemostatic dysfunction and allows for both the prediction and monitoring from non-overt to overt DIC. As its performance is simple and rapid, this provides the means for targeting therapeutic intervention to an earlier stage of DIC. The recent identification that the mechanism underlying the biphasic waveform is a complex that exists in vivo between C reactive protein with very low density lipoprotein, provides potentially important insights into the molecular pathogenesis of DIC. Thus, in addition to the immediate clinical utility in diagnostic practice, it has important applications as a research tool. Preliminary experience in the application of this technology to the diagnosis and management of the haemophilias and the lupus anticoagulant syndrome has also provided evidence of the power and utility of waveform analysis in essentially simple clotting assays.
机译：透射率波形图绘制了标准凝血测定中的透射率变化，例如凝血酶原时间（PT）和活化的部分凝血活酶时间（APTT）。在光凝固分析仪上对这些数据的分析和表征提供了仅使用凝血时间所获得的定性和定量信息。评估最充分的临床应用是具有弥散性血管内凝血（DIC）的双相APTT波形。波形异常的程度与止血功能障碍的严重程度直接相关，并允许从非公开的DIC到公开的DIC进行预测和监视。由于其操作简便，快速，因此提供了将治疗干预针对DIC早期阶段的方法。最近鉴定为双相波形的机制是体内存在的C反应蛋白与极低密度脂蛋白之间的复合物，这为DIC的分子发病机理提供了潜在的重要见解。因此，除了在诊断实践中具有直接的临床用途外，它还作为研究工具具有重要的应用。在将该技术用于血友病和狼疮抗凝综合症的诊断和管理中的应用的初步经验还提供了在基本简单的凝血测定中进行波形分析的强大功能和实用性的证据。

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