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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Association of Apoliprotein E polymorphisms and metabolic syndrome in subjects with extreme obesity.
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Association of Apoliprotein E polymorphisms and metabolic syndrome in subjects with extreme obesity.

机译：极度肥胖的受试者中载脂蛋白E多态性与代谢综合征的关联。

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摘要

BACKGROUND: Obesity has been linked to metabolic syndrome (MS), which increases the risk of cardiovascular disease (CVD). Polymorphisms of Apolipoprotein E have also been associated with increased CVD risk. Therefore, this study investigated the association between MS and Apo E polymorphisms. METHODS: We measured anthropometric and biochemical variables and determined the Apo E genotype of 147 grade III obese patients. RESULTS: The percentage of female subjects was 86.4%. The mean age and BMI of the subjects were 41 years and 53.5 kg/m(2), respectively. MS had been diagnosed in 79% of the subjects. The proportions of those exhibiting MS risk factors were as follows: 100% had a high BMI, 80% had hypertension, 65% had low levels of high-density lipoprotein (HDL), 38% had diabetes, and 39% had hypertriglyceridemia. We found five genotypes for which the allelic distribution was different in the MS group compared to the general population. The epsilon4 allele was more frequent in the group with neither MS nor hypertension. CONCLUSIONS: The morbidly obese patients exhibited a higher incidence of MS and a different allelic distribution when compared with other populations. The epsilon4 allele was associated with the absence of MS and hypertension.
机译：背景：肥胖症与代谢综合征（MS）有关，而代谢综合征会增加心血管疾病（CVD）的风险。载脂蛋白E的多态性也与CVD风险增加有关。因此，本研究调查了MS与Apo E多态性之间的关联。方法：我们测量了人体测量学和生化指标，并确定了147位III级肥胖患者的Apo E基因型。结果：女性受试者的比例为86.4％。受试者的平均年龄和BMI分别为41岁和53.5 kg / m（2）。已在79％的受试者中诊断出MS。那些表现出MS危险因素的人群的比例如下：100％的BMI高，80％的高血压，65％的高密度脂蛋白（HDL）水平低，38％的糖尿病和39％的高甘油三酯血症。我们发现与普通人群相比，MS组中等位基因分布不同的五种基因型。在既没有MS也没有高血压的人群中，epsilon4等位基因更为频繁。结论：与其他人群相比，病态肥胖患者表现出更高的MS发生率和不同的等位基因分布。 epsilon4等位基因与MS和高血压的缺乏有关。

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