SYNTHESIS, CRYSTAL STRUCTURE, AND IN VITRO ANTITUMOR ACTIVITY OF A NOVEL TETRANUCLEAR DI-N-BUTYLTIN(IV)

HE H.B.; GE X.L.; RUAN B.F.

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SYNTHESIS, CRYSTAL STRUCTURE, AND IN VITRO ANTITUMOR ACTIVITY OF A NOVEL TETRANUCLEAR DI-N-BUTYLTIN(IV)

机译：新型四核二正丁基锡（IV）的合成，晶体结构和体外抗肿瘤活性

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A di-n-butyltin(IV) complex with (E)-3-(4-(9H-carbazole-9-yl)phenyl) acrylic acid (HL) of the formula {[n-Bu_2SnOL]_2O}_2 was synthesized and characterized by X-ray crystallography. This complex is a tetranucle-ar one with ladder framework. Furthermore, this complex was tested in vitro for its cytotoxic activity, using human hepatocellular carcinoma cell line (BEL-7402) and human hepatocellular liver carcinoma cell line (HepG2); 5-Fluorouracil was used as a positive control substance. This complex showed cytotoxicity greater than that of 5-Fluorouracil.

机译：合成了具有{{n-Bu_2SnOL] _2O} _2的（E）-3-（4-（9H-咔唑-9-基）苯基）丙烯酸（HL）的二正丁基锡（IV）配合物并且通过X射线晶体学表征。该复合物是具有梯形框架的四核结构。此外，使用人肝细胞癌细胞系（BEL-7402）和人肝细胞肝癌细胞系（HepG2）在体外测试了该复合物的细胞毒性活性。 5-氟尿嘧啶用作阳性对照物质。该复合物显示出比5-氟尿嘧啶更大的细胞毒性。

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《Координационная химия》 |2013年第8期|共5页
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HE H.B.; GE X.L.; RUAN B.F.;
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SYNTHESIS, CRYSTAL STRUCTURE, AND IN VITRO ANTITUMOR ACTIVITY OF A NOVEL TETRANUCLEAR DI-N-BUTYLTIN(IV)

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