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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Thiol compounds metabolism in mice, rats and humans: Comparative study and potential explanation of rodents protection against vascular diseases.
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Thiol compounds metabolism in mice, rats and humans: Comparative study and potential explanation of rodents protection against vascular diseases.

机译：硫醇类化合物在小鼠，大鼠和人类中的代谢：啮齿动物对血管疾病的保护作用的比较研究和潜在解释。

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BACKGROUND: Rodents are often used as animal models to dissect mechanisms underlying hyperhomocysteinemia atherogenicity in humans. However, neither wild-type rodents nor cystathionine beta-synthase deficient mice develop spontaneous atherosclerosis. We investigated whether species-specific differences in thiols metabolism may explain the respective sensitivity of rodents and humans to hyperhomocysteinemia. METHODS: Thiols and vitamins B levels were determined in normohomocysteinemic humans and rodents, and in hyperhomocysteinemic mice. RESULTS: In basal status, although plasma homocysteine, cysteine and cysteinylglycine levels were lower, glutathione levels were higher in mice than in humans (4.0+/-1.6 vs. 7.9+/-2.2, P<0.0005; 147.4+/-40.3 vs. 278.5+/-50.0, P<0.0001; 2.3+/-0.7 vs. 36.6+/-7.3, P<0.0001; and 70.9+/-20.1 vs. 4.6+/-1.6, P<0.0001). Serum vitamin B12 and folate levels were 2.5- and 7.7-fold higher in rats than in humans. In wild-type mice, the increase in plasma Hcy levels induced by methionine-enriched diet was accompanied by a proportional increase in GSH levels. CONCLUSION: GSH levels are enough to modulate Hcy effects in normo- and hyperhomocysteinemic mice but not in humans. This rodents characteristic, likely supported by species differences in the relative contribution of remethylation and transsulfuration pathways, may partly explain their protection against atherosclerosis.
机译：背景：啮齿动物通常用作动物模型，以剖析人类高同型半胱氨酸血症致动脉粥样硬化性的机制。但是，野生型啮齿动物和胱硫醚β-合酶缺陷型小鼠均未发生自发性动脉粥样硬化。我们调查了硫醇代谢中物种特异性的差异是否可以解释啮齿动物和人类对高同型半胱氨酸血症的敏感性。方法：测定正常同型半胱氨酸血症的人和啮齿动物以及高同型半胱氨酸血症的小鼠中的硫醇和维生素B水平。结果：在基础状态下，尽管血浆同型半胱氨酸，半胱氨酸和半胱氨酰甘氨酸水平较低，但小鼠中的谷胱甘肽水平却高于人类（4.0 +/- 1.6对7.9 +/- 2.2，P <0.0005; 147.4 +/- 40.3对278.5 +/- 50.0，P <0.0001; 2.3 +/- 0.7与36.6 +/- 7.3，P <0.0001;和70.9 +/- 20.1与4.6 +/- 1.6，P <0.0001）。大鼠的血清维生素B12和叶酸水平比人高2.5倍和7.7倍。在野生型小鼠中，富含蛋氨酸的饮食诱导的血浆Hcy水平升高，同时GSH水平成比例增加。结论：谷胱甘肽水平足以调节正常和高同型半胱氨酸血症小鼠的Hcy效应，但对人类却没有。这种啮齿动物的特征很可能受到物种在再甲基化和转硫途径相对贡献方面的差异的支持，这可能部分解释了它们对动脉粥样硬化的保护作用。

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