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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Plasma 8-iso-Prostaglandin F2alpha concentrations and outcomes after acute intracerebral hemorrhage
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Plasma 8-iso-Prostaglandin F2alpha concentrations and outcomes after acute intracerebral hemorrhage

机译：急性脑出血后血浆8-异前列腺素F2alpha浓度和预后

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Background: Higher plasma 8-iso-Prostaglandin F2alpha concentrations have been associated with poor outcome of severe traumatic brain injury. We further investigated the relationships between plasma 8-iso-Prostaglandin F2alpha concentrations and clinical outcomes in patients with acute intracerebral hemorrhage. Methods: Plasma 8-iso-Prostaglandin F2alpha concentrations of 128 consecutive patients and 128 sex- and gender-matched healthy subjects were measured by enzyme-linked immunosorbent assay. We assessed their relationships with disease severity and clinical outcomes including 1-week mortality, 6-month mortality and unfavorable outcome (modified Rankin Scale score > 2).Results: Plasma 8-iso-Prostaglandin F2alpha concentrations were substantially higher in patients than in healthy controls. Plasma 8-iso-Prostaglandin F2alpha concentrations were positively associated with National Institutes of Health Stroke Scale (NIHSS) scores and hematoma volume using a multivariate linear regression. It emerged as an independent predictor for clinical outcomes of patients using a forward stepwise logistic regression. ROC curves identified the predictive values of plasma 8-iso-Prostaglandin F2alpha concentrations, and found its predictive value was similar to NIHSS scores and hematoma volumes. However, it just numerically added the predictive values of NIHSS score and hematoma volume.Conclusions: Increased plasma 8-iso-Prostaglandin F2alpha concentrations are associated with disease severity and clinical outcome after acute intracerebral hemorrhage.
机译：背景：血浆8-异前列腺素F2alpha浓度升高与严重的颅脑外伤结果差有关。我们进一步调查了急性脑出血患者血浆8-异前列腺素F2alpha浓度与临床结局之间的关系。方法：采用酶联免疫吸附法测定了128名连续患者以及128名性别和性别匹配的健康受试者的血浆8-异前列腺素F2alpha浓度。我们评估了他们与疾病严重程度和临床结局的关系，包括1周死亡率，6个月死亡率和不利结果（改良的Rankin量表评分> 2）。结果：患者血浆8-异前列腺素F2alpha浓度明显高于健康人群控件。使用多元线性回归，血浆8-异前列腺素F2alpha浓度与国立卫生研究院卒中量表（NIHSS）评分和血肿量呈正相关。使用前向逐步逻辑回归，它已成为患者临床结果的独立预测指标。 ROC曲线确定了血浆8-异前列腺素F2alpha浓度的预测值，发现其预测值与NIHSS评分和血肿量相似。然而，它只是在数值上增加了NIHSS评分和血肿体积的预测值。结论：血浆8-异前列腺素F2alpha浓度升高与急性脑出血后疾病的严重程度和临床结局有关。

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