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首页> 外文期刊>Clinica chimica acta: International journal of clinical chemistry and applied molecular biology >Distribution of aluminum in hair of Brazilian infants and correlation to aluminum-adjuvanted vaccine exposure
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Distribution of aluminum in hair of Brazilian infants and correlation to aluminum-adjuvanted vaccine exposure

机译：巴西婴儿头发中铝的分布及其与铝佐剂疫苗暴露的关系

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Background: Nursing children are exposed to dietary aluminum (in breast milk and/or infant formulas) and through aluminum-adjuvanted vaccines (AAVs). We studied total hair-Al concentrations of nursing children that had been immunized with hepatitis B, DTP, and meningococcal vaccines. Methods: We studied the hair of 37 young children (aged 26 to 824. days) who were exposed to cumulative doses of Al ranging from 0.63 to 6.88. mg from AAVs. Graphite furnace atomic absorption spectrometry was used to reliably measure total Al concentrations in hair samples. Results: The analytical method proved sensitive enough to quantify Al in the hair of nursing children. At current levels of exposure it is possible to determine total Al in hair sample of 1.65mg. Cumulative doses of AAV in children ranged from 0.63 to 6.88mg Al. Median hair-Al was 47.7μgg-1 (ranging from 12.2 to 221.9μgg-1). There was no statistically significant correlation between hair-Al concentration and age of child (r=-0.049; p=0.774), total exposure from vaccine (r=-0.078; p=0.643), or the time elapsed after the last AAVs (r=0.015; p=0.931). Conclusion: Aluminum in children's hair can be reliably measured but we are still uncertain how representative it can be of the Al body burden.
机译：背景：护理儿童要通过饮食中的铝（以母乳和/或婴儿配方奶粉）和铝辅助疫苗（AAV）接触。我们研究了用乙型肝炎，DTP和脑膜炎球菌疫苗免疫的哺乳儿童的总Al-Al浓度。方法：我们研究了37名年龄在26至824.天的幼儿的头发，这些头发暴露于累积剂量为0.63至6.88的Al。毫克来自AAV。石墨炉原子吸收光谱法用于可靠地测量头发样品中的总铝浓度。结果：该分析方法被证明足够灵敏，可以定量护理儿童头发中的铝。在目前的暴露水平下，可以测定头发样品中的总Al为1.65mg。儿童的AAV累积剂量范围为0.63至6.88mg Al。头发A1的中位数为47.7μgg-1（范围从12.2至221.9μgg-1）。头发中的Al浓度与儿童年龄（r = -0.049; p = 0.774），疫苗的总暴露量（r = -0.078; p = 0.643）或最后一次AAV接种后所经过的时间之间无统计学意义的相关性（ r ＝ 0.015; p ＝ 0.931）。结论：可以可靠地测量儿童头发中的铝，但我们仍不确定铝对人体负担的代表性。

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