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首页> 外文期刊>Clinical & developmental immunology. >PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response
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PD-L1 Expression Induced by the 2009 Pandemic Influenza A(H1N1) Virus Impairs the Human T Cell Response

机译：2009大流行性流感A（H1N1）病毒诱导的PD-L1表达损害人类T细胞反应

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摘要

PD-L1 expression plays a critical role in the impairment of T cell responses during chronic infections; however, the expression of PD-Ll on T cells during acute viral infections, particularly during the pandemic influenza virus (A(HlNl)pdm09), and its effects on the T cell response have not been widely explored. We found that A(HlNl)pdm09 virus induced PD-L1 expression on human dendritic cells (DCs) and T cells, as well as PD-1 expression on T cells. PD-L1 expression impaired the T cell response against A(HlNl)pdmO9 by promoting CD8~+ T cell death and reducing cytokine production. Furthermore, we found increased PD-L1 expression on DCs and T cells from influenza-infected patients from the first and second 2009 pandemic waves in Mexico City. PD-L1 expression on CD8~+ T cells correlated inversely with T cell proportions in patients infected with A(HlNl)pdm09. Therefore, PD-L1 expression on DCs and T cells could be associated with an impaired T cell response during acute infection with A(HlNl)pdm09 virus.
机译：在慢性感染过程中，PD-L1的表达在T细胞反应的损伤中起着至关重要的作用。然而，PD-L1在急性病毒感染期间，特别是在大流行性流感病毒（A（H1N1）pdm09）期间在T细胞上的表达及其对T细胞应答的影响尚未得到广泛研究。我们发现A（HlN1）pdm09病毒诱导人树突状细胞（DC）和T细胞上的PD-L1表达，以及T细胞上的PD-1表达。 PD-L1的表达通过促进CD8〜+ T细胞死亡并减少细胞因子的产生而损害了针对A（HlNl）pdmO9的T细胞反应。此外，我们发现墨西哥城2009年第一次和第二次大流行波感染流感的患者的DC和T细胞上PD-L1表达增加。在感染了A（H1N1）pdm09的患者中，CD8〜+ T细胞上PD-L1的表达与T细胞比例成反比。因此，在急性感染A（H1N1）pdm09病毒期间，DC和T细胞上的PD-L1表达可能与受损的T细胞反应有关。

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