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首页> 外文期刊>Clinical & developmental immunology. >The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome
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The Immune Factors Involved in the Pathogenesis, Diagnosis, and Treatment of Sjogren's Syndrome

机译：干燥综合征的发病机制，诊断和治疗涉及的免疫因素

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Sjogren's syndrome (SS) is a systemic, autoimmune disorder characterized by salivary insufficiency and lymphocytic infiltration of the exocrine glands. Even though the mechanism of its pathology and progression has been researched ever since its discovery, the roles of different parts of immune system remain inconclusive. There is no straightforward and simple theory for the pathogenesis and diagnosis of Sjogreris syndrome because of the multiple kinds and functions of autoantibodies, changing proportion of different T-lymphocyte subsets with the progression of disease, unsuspected abilities of B lymphocytes discovered recently, crosstalk between cytokines connecting the factors mentioned previously, and genetic predisposition that contributes to the initiation of this disease. On the other hand, the number of significant reports and open-label studies of B-cell depletion therapy showing clinical efficacy in sjogren's syndrome has continued to accumulate, which provides a promising future for the patients. In a word, further elucidation of the role of different components of the immune system will open avenues for better diagnosis and treatment of SS, whose current management is still mainly supportive.
机译：干燥综合征（SS）是一种全身性自身免疫性疾病，其特征是唾液功能不全和外分泌腺的淋巴细胞浸润。尽管自发现以来就对其病理学和进展机制进行了研究，但免疫系统不同部分的作用仍未定论。 Sjogreris综合征的发病机理和诊断没有简单明了的理论，因为自身抗体的种类和功能多种多样，随着疾病的发展，不同的T淋巴细胞亚群的比例不断变化，最近发现的B淋巴细胞毫无怀疑的能力，细胞因子之间的相互干扰连接前面提到的因素，以及导致这种疾病发作的遗传易感性。另一方面，B细胞耗竭疗法的大量报告和开放标签研究表明，在干燥综合征中的临床疗效不断增加，这为患者提供了有希望的未来。简而言之，进一步阐明免疫系统不同组成部分的作用将为更好地诊断和治疗SS开辟道路，SS的当前管理仍主要是支持性的。

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