• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical & developmental immunology. >Role of Thl7 Cells in Skin Inflammation of Allergic Contact Dermatits
【24h】

Role of Thl7 Cells in Skin Inflammation of Allergic Contact Dermatits

机译：Thl7细胞在过敏性接触性皮炎的皮肤炎症中的作用

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Extending the classical concept considering an imbalance exclusively of T helper(h) 1 and 1112 cells on the bottom of many inflammatory diseases, 1hl7 cells were recently described. Today, there is sufficient experimental evidence to classify psoriasis and allergic contact dermatitis (ACD) amongst other inflammatory skin disorders as IL-17 associated diseases. In several human studies, T-cell-clones could be isolated from eczema biopsies, and high IL-17 levels were observed after challenge with allergen. In the last years, the phenotype of these IL-17 releasing T cells was in the focus of discussion. It has been suggested that Th17 could be identified by expression of retinoic acid receptor-related orphan receptor (ROR)C (humans) or RORgammat (mice) and IL-17, accompanied by the absence of IFN-gamma and IL-22. In cells from skin biopsies, contact allergens elevate IL-17 A, IL-23, and RORC within the subset of Th cells. The indications for a participation of 1hl7 in the development of ACD are supported by data from IL-17 deficient mice with reduced contact hypersensitivity (CHS) reactions that could be restored after transplantation of wild type CD4~+ T cells. In addition to Thl7 cells, subpopulations of CD8~+ T cells and regulatory T cells are further sources of IL-17 that play important roles in ACD as well. Finally, the results from Thl7 cell research allow today identification of different skin diseases by a specific profile of signature cytokines from Th cells that can be used as a future diagnostic tool.
机译：在许多炎症性疾病的底部扩展了仅考虑T辅助细胞（h）1和1112细胞失衡的经典概念时，最近描述了1hl7细胞。如今，有足够的实验证据将银屑病和过敏性接触性皮炎（ACD）归类为其他炎症性皮肤病和IL-17相关疾病。在一些人体研究中，可以从湿疹活检组织中分离出T细胞克隆，在用过敏原攻击后观察到高的IL-17水平。在最近几年中，这些IL-17释放的T细胞的表型成为讨论的焦点。已经提出，可以通过与视黄酸受体相关的孤儿受体（ROR）C（人）或RORgammat（小鼠）和IL-17的表达来鉴定Th17，并伴有IFN-γ和IL-22的缺失。在皮肤活检细胞中，接触过敏原会升高Th细胞亚群内的IL-17 A，IL-23和RORC。来自IL-17缺陷型小鼠的具有降低的接触超敏性（CHS）反应的数据支持了1hl7参与ACD的发展的迹象，这些数据可在野生型CD4 + T细胞移植后得以恢复。除了Thl7细胞外，CD8〜+ T细胞和调节性T细胞的亚群也是IL-17的进一步来源，它们在ACD中也起着重要的作用。最后，Th17细胞研究的结果使今天可以通过Th细胞特征性细胞因子的特定特征来鉴定不同的皮肤疾病，这些特征可以用作未来的诊断工具。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号