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The influences of nitrous oxide and ketamine on electroencephalogram during propofol-anesthesia

机译：一氧化二氮和氯胺酮对异丙酚麻醉期间脑电图的影响

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BACKGROUND: The influence of nitrous oxide and ketamine on electroencephalogram (EEG) during the induction of general anesthesia with propofol was quantitatively analyzed. METHODS: Anesthesia was induced with propofol using TCI (target controlled infusion) system. Twenty-five adult patients (ASA I-II) were randomly divided into three groups: 1. anesthesia induced with propofol alone [Group-P (n=7)], 2. anesthesia induced with inhalation of nitrous oxide in addition to propofol [Group-PN (n= 10)] and 3. anesthesia induced with intravenous injection of ketamine in addition to propofol [Group-PK (n= 8)]. We studied the influence of nitrous oxide and ketamine on EEG by analyzing the relations between effect-site concentration of propofol and EEG-indices. RESULTS: Additional injection of ketamine (Group-PK) increased BIS index during the maintenance of anesthesia from 43.4 +/- 8.2 to 71.8 +/- 6.5 in comparison with the contrasting group (Group-P). Nitrous oxide also increased the high frequency component inEEG. CONCLUSIONS: When anesthesia is induced with nitrous oxide and/or ketamine together with propofol, and BIS is taken as an index of depth of anesthesia, the intracerebral concentration of propofol becomes excess.
机译：背景：定量分析了异丙酚诱导全身麻醉过程中一氧化二氮和氯胺酮对脑电图（EEG）的影响。方法：使用TCI（靶控输注）系统用异丙酚诱导麻醉。 25例成年患者（ASA I-II）随机分为三组：1.单独使用异丙酚诱导的麻醉[Group-P（n = 7）]; 2.吸入除异丙酚之外的一氧化二氮引起的麻醉[ PN组（n = 10）]和3.异丙酚[PK组（n = 8）]静脉内注射氯胺酮引起的麻醉。通过分析异丙酚的有效部位浓度与脑电图指标之间的关系，研究了一氧化二氮和氯胺酮对脑电图的影响。结果：与对比组（P组）相比，氯胺酮（PK组）在维持麻醉期间的BIS指数从43.4 +/- 8.2增加到71.8 +/- 6.5。一氧化二氮也增加了脑电图的高频成分。结论：当一氧化二氮和/或氯胺酮与丙泊酚一起诱导麻醉时，以BIS作为麻醉深度的指标时，丙泊酚的脑内浓度过高。

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