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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >A SAS macro for direct adjusted survival curves based on Aalen's additive model
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A SAS macro for direct adjusted survival curves based on Aalen's additive model

机译：基于Aalen加法模型的直接调整生存曲线的SAS宏

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摘要

Aalen's additive model defines the covariate effects on the survival outcome to be time-varying. The aim of this paper is to explore the application of Aalen's model in assessing treatment effects, adjusting for possibly different patient profiles between the treatment groups. We treat Aalen's model as the underlying model and compute the direct adjusted survival curves for different treatments. The treatment comparison can be performed by finding a confidence interval for the difference between two direct adjusted survivals. We developed a SAS macro that calculates the direct adjusted survival estimates and the standard errors, based on Aalen's model. In this paper, we give two examples to explain the syntax for using the macro.
机译：Aalen的加性模型将对生存结果的协变量影响定义为随时间变化。本文的目的是探索Aalen模型在评估治疗效果中的应用，并针对治疗组之间可能不同的患者情况进行调整。我们将Aalen模型作为基础模型，并针对不同治疗方法计算直接调整后的生存曲线。可以通过找到两个直接调整的生存期之间差异的置信区间来进行治疗比较。我们开发了一个SAS宏，可基于Aalen模型计算直接调整的生存期估计值和标准误差。在本文中，我们给出两个示例来说明使用宏的语法。

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