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首页> 外文期刊>Computer Methods and Programs in Biomedicine: An International Journal Devoted to the Development, Implementation and Exchange of Computing Methodology and Software Systems in Biomedical Research and Medical Practice >Development and pilot testing of the Neuromuscular Blockade Advisory System.
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Development and pilot testing of the Neuromuscular Blockade Advisory System.

机译：神经肌肉封锁咨询系统的开发和试点测试。

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摘要

The neuromuscular blocker advisory system (NMBAS) is a computer program developed to provide advisory guidance to anesthesiologists on the timing and dose of rocuronium to paralyze patients during surgery. It is believed that the use of such a system will administer the minimally effective amount of drug, maintaining the patient in a state of paralysis that is useful for surgery yet easily reversible. This will improve patient safety and result in more efficient care. In this paper we present the NMBAS, its basic methodology, and its development though a pilot study. Novel methods of handling neuromuscular response data are presented, including relaxation measurement and the enhanced-train-of-four sensing modality. New methods of handling nonlinearities at the neuromuscular junction to allow application of adaptive control techniques are presented. A novel form of modelling combining model swapping and RLSE adaptation to accommodate the patient variation seen with NMB drugs is introduced. A pilot studytesting the NMBAS was undergone to prepare the NMBAS for application in a full clinical trial, in which patients undergoing prostate brachytherapy surgeries using rocuronium for intubation were admitted.
机译：神经肌肉阻滞剂咨询系统（NMBAS）是一种计算机程序，旨在为麻醉医师在手术期间使罗库溴铵麻痹患者的时间和剂量提供咨询指导。相信使用这种系统将施用最小有效量的药物，从而使患者处于对手术有用但易于逆转的瘫痪状态。这将改善患者的安全性并导致更有效的护理。在本文中，我们通过初步研究介绍了NMBAS，其基本方法及其发展。提出了处理神经肌肉反应数据的新方法，包括松弛测量和增强的四列火车感知方式。提出了处理神经肌肉连接处的非线性以允许应用自适应控制技术的新方法。介绍了一种新颖的建模形式，结合了模型交换和RLSE适应功能，以适应NMB药物所见的患者差异。进行了一项测试NMBAS的试验研究，以准备将NMBAS应用于完整的临床试验，该试验允许接受使用罗库溴铵进行插管的前列腺近距离放射疗法手术的患者。

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