The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

van der Mark Vincent A.; de Waart D. Rudi; Ho-Mok Kam S.; Tabbers Merit M.; Voogt Heleen W.; Elferink Ronald P. J. Oude; Knisely A. S.; Paulusma Coen C.

首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

【24h】

The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

机译：脂质翻转酶异二聚体ATP8B1-CDC50A对于肠Caco-2细胞中根尖钠依赖性胆汁酸转运蛋白（SLC10A2 / ASBT）的表面表达至关重要

获取原文

获取原文并翻译 | 示例

掌桥外文数据库（机构版） >>

开具论文收录证明 >>

文献代查 >>

页面导航

摘要
著录项
相似文献
相关主题

摘要

Deficiency of the phospholipid flippase ATPase, aminophospholipid transporter, class I, type 8B, member 1 (ATP8B1) causes progressive familial intrahepatic cholestasis type 1 (PFIC1) and benign recurrent intrahepatic cholestasis type I (BRIC1). Apart from cholestasis, many patients also suffer from diarrhea of yet unknown etiology. Here we have studied the hypothesis that intestinal ATP8B1 deficiency results in bile salt malabsorption as a possible cause of PFIC1/BRIC1 diarrhea.

机译：磷脂翻转酶ATPase，I类，8B型，成员1（ATP8B1）的氨基磷脂转运蛋白缺乏会导致进行性家族性肝内胆汁淤积1型（PFIC1）和良性复发性肝内胆汁淤积I型（BRIC1）。除了胆汁淤积，许多患者还患有病因不明的腹泻。在这里，我们研究了肠道ATP8B1缺乏导致胆盐吸收不良的假说，这可能是PFIC1 / BRIC1腹泻的可能原因。

著录项

来源
《Biochimica et biophysica acta. Molecular basis of disease: BBA》 |2014年第1期|共9页
作者
van der Mark Vincent A.; de Waart D. Rudi; Ho-Mok Kam S.; Tabbers Merit M.; Voogt Heleen W.; Elferink Ronald P. J. Oude; Knisely A. S.; Paulusma Coen C.;
展开▼
作者单位

展开▼
收录信息
原文格式 PDF
正文语种 eng
中图分类分子生物学;
关键词
PFIC1; ATP8B1; SLC10A2; Enterohepatic circulation; Diarrhea;

机译：PFIC1;ATP8B1;SLC10A2;肠肝循环;腹泻;

相似文献

外文文献
专利

1. The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells [J] . van der Mark Vincent A., de Waart D. Rudi, Ho-Mok Kam S., Biochimica et biophysica acta. Molecular basis of disease: BBA . 2014,第12aPta1期

机译：脂质翻转酶异二聚体ATP8B1-CDC50A对于肠Caco-2细胞中根尖钠依赖性胆汁酸转运蛋白（SLC10A2 / ASBT）的表面表达至关重要
2. An important intestinal transporter that regulates the enterohepatic circulation of bile acids and cholesterol homeostasis: The apical sodium-dependent bile acid transporter (SLC10A2/ASBT) [J] . Ling Xiao, Guoyu Pan Clinics and research in hepatology and gastroenterology . 2017,第5期

机译：一种重要的肠道转运蛋白，调节胆汁酸和胆固醇稳态的肠溶血液循环：顶端钠依赖性胆汁酸转运蛋白（SLC10A2 / ASBT）
3. Enterobacteria modulate intestinal bile acid transport and homeostasis through apical sodium-dependent bile acid transporter (SLC10A2) expression. [J] . Miyata M, Yamakawa H, Hamatsu M, The Journal of Pharmacology and Experimental Therapeutics: Official Publication of the American Society for Pharmacology and Experimental Therapeutics . 2011,第1期

机译：肠杆菌通过根尖钠依赖性胆汁酸转运蛋白（SLC10A2）的表达来调节肠道胆汁酸转运和体内稳态。
4. Understanding structure-function relationships and protein stability of the human apical sodium-dependent bile acid transporter (ASBT, SLC10A2). [D] . Claro da Silva, Tatiana. 2011

机译：了解人心钠依赖性胆汁酸转运蛋白（ASBT，SLC10A2）的结构-功能关系和蛋白质稳定性。
5. Functional Characterization of Genetic Variants in the Apical Sodium-Dependent Bile Acid Transporter (ASBT; SLC10A2) [O] . Richard H. Ho, Brenda F. Leake, Brad L. Urquhart, -1

机译：顶端依赖性胆汁酸转运蛋白遗传变体的功能表征（ASBT; SLC10A2）
6. The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells [O] . van der Mark, Vincent A., de Waart, D. Rudi, Ho-Mok, Kam S., 2014

机译：脂质脂酶异二聚体ATP8B1-CDC50A对于肠Caco-2细胞中根尖钠依赖性胆汁酸转运蛋白（SLC10A2 / ASBT）的表面表达至关重要

The lipid flippase heterodimer ATP8B1-CDC50A is essential for surface expression of the apical sodium-dependent bile acid transporter (SLC10A2/ASBT) in intestinal Caco-2 cells

摘要

著录项

相似文献

相关主题

期刊订阅