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首页> 外文期刊>Clinical and experimental allergy : >Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis.
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Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis.

机译：干酪乳杆菌Shirota的口服给药可改变变应性鼻炎中变应原诱导的免疫反应。

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BACKGROUND: Changes in the composition of the gut microbiota have been implicated in the pathogenesis of allergic disorders, suggesting beneficial interactions between the intestinal immune system and specific bacterial strains. Lactobacilli are naturally present within the complex gastrointestinal microbiota of humans and they are currently present in many probiotic supplements. OBJECTIVE: We sought to investigate the role that Lactobacillus casei Shirota (LcS) may play in modulating seasonal allergic rhinitis (SAR). METHODS: The study format was double-blinded, placebo-controlled with 10 SAR sufferers in each group. We have documented and compared changes in immune status arising through the daily ingestion of a milk drink with or without live LcS, over a period of 5 months. Pre-, peak- and post-grass pollen season blood samples were collected for determination of plasma total IgE and grass pollen-specific IgG and IgE levels by an enzyme immunoassay. At the same time, cytokine levels were determined by flow cytometric bead array technology following culture of peripheral blood mononuclear cells for 6 days in the presence or absence of specific grass pollen antigens. RESULTS: Volunteers treated with LcS showed a significant reduction in levels of antigen-induced IL-5, IL-6 and IFN-gamma production compared with volunteers supplemented with placebo. Meanwhile, levels of specific IgG increased and IgE decreased in the probiotic group. CONCLUSION: Changes in antigen-induced production of cytokines were observed in patients treated with probiotics. These data show that probiotic supplementation modulates immune responses in allergic rhinitis and may have the potential to alleviate the severity of symptoms.
机译：背景：肠道菌群组成的变化与过敏性疾病的发病机制有关，表明肠道免疫系统与特定细菌菌株之间存在有益的相互作用。乳酸杆菌天然存在于人类复杂的胃肠道菌群中，目前存在于许多益生菌补品中。目的：我们试图研究干酪乳杆菌Shirota（LcS）在调节季节性变应性鼻炎（SAR）中的作用。方法：研究形式为双盲，安慰剂对照，每组10名SAR患者。我们已经记录并比较了在5个月内每天摄入有或没有活LcS的牛奶饮料引起的免疫状态变化。采集草前，高峰和后花粉季节的血样，通过酶免疫测定法测定血浆总IgE和草花粉特异性IgG和IgE水平。同时，在存在或不存在特定草花粉抗原的情况下，将外周血单核细胞培养6天后，通过流式细胞术微珠阵列技术测定细胞因子水平。结果：与补充安慰剂的志愿者相比，接受LcS治疗的志愿者的抗原诱导的IL-5，IL-6和IFN-γ产生水平显着降低。同时，益生菌组中特异性IgG的水平升高而IgE降低。结论：在益生菌治疗的患者中观察到了抗原诱导的细胞因子产生的变化。这些数据表明，益生菌补充剂可调节变应性鼻炎的免疫反应，并可能减轻症状的严重性。

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