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首页> 外文期刊>Clinical and experimental allergy : >Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis.
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Oral delivery of Lactobacillus casei Shirota modifies allergen-induced immune responses in allergic rhinitis.

机译：口服递送乳酸杆菌Shirota在过敏性鼻炎中改变过敏原诱导的免疫应答。

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BACKGROUND: Changes in the composition of the gut microbiota have been implicated in the pathogenesis of allergic disorders, suggesting beneficial interactions between the intestinal immune system and specific bacterial strains. Lactobacilli are naturally present within the complex gastrointestinal microbiota of humans and they are currently present in many probiotic supplements. OBJECTIVE: We sought to investigate the role that Lactobacillus casei Shirota (LcS) may play in modulating seasonal allergic rhinitis (SAR). METHODS: The study format was double-blinded, placebo-controlled with 10 SAR sufferers in each group. We have documented and compared changes in immune status arising through the daily ingestion of a milk drink with or without live LcS, over a period of 5 months. Pre-, peak- and post-grass pollen season blood samples were collected for determination of plasma total IgE and grass pollen-specific IgG and IgE levels by an enzyme immunoassay. At the same time, cytokine levels were determined by flow cytometric bead array technology following culture of peripheral blood mononuclear cells for 6 days in the presence or absence of specific grass pollen antigens. RESULTS: Volunteers treated with LcS showed a significant reduction in levels of antigen-induced IL-5, IL-6 and IFN-gamma production compared with volunteers supplemented with placebo. Meanwhile, levels of specific IgG increased and IgE decreased in the probiotic group. CONCLUSION: Changes in antigen-induced production of cytokines were observed in patients treated with probiotics. These data show that probiotic supplementation modulates immune responses in allergic rhinitis and may have the potential to alleviate the severity of symptoms.
机译：背景技术：肠道微生物组成的变化涉及过敏性疾病的发病机制，表明肠免疫系统和特异性细菌菌株之间有益相互作用。乳酸杆菌天然存在于人类的复杂胃肠微生物群内，目前存在于许多益生菌补充剂中。目的：我们试图探讨乳酸杆菌（LCS）在调节季节性过敏性鼻炎（SAR）中可能发挥的作用。方法：研究格式是双盲的，安慰剂控制，每组10个SAR患者。我们已经记录了并在5个月内每天摄取牛奶饮料的每日摄取，通过每日摄入牛奶饮料而产生的免疫状态的变化。收集了预先，峰和草后花粉季血液样品，用于通过酶免疫测定法测定血浆总IgE和草花粉特异性IgG和IgE水平。同时，通过流式细胞术珠阵列技术在外周血单核细胞培养到存在或不存在特定草花粉抗原的情况下，通过流式细胞术珠阵列技术确定细胞因子水平。结果：用LCS治疗的志愿者表现出抗原诱导的IL-5，IL-6和IFN-Gamma生产水平的显着降低，与补充安慰剂的志愿者相比。同时，益生菌组中，特异性IgG的水平和IgE降低。结论：益生菌治疗的患者中观察到抗原诱导的细胞因子产生的变化。这些数据显示，益生菌补充剂调节过敏性鼻炎中的免疫应答，可能有可能减轻症状的严重程度。

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