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首页> 外文期刊>Clinical and experimental allergy : >Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria.
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Brain-derived neurotrophic factor is increased in serum and skin levels of patients with chronic spontaneous urticaria.

机译：慢性自发性荨麻疹患者的血清和皮肤中脑源性神经营养因子增加。

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Background Chronic spontaneous urticaria is triggered by many direct and indirect aggravating factors including autoreactive/autoimmune mechanisms, infections, non-allergic and pseudoallergic intolerance reactions. However, the role of neuroimmune mechanisms in chronic spontaneous urticaria so far is unclear. Objective Thus, we wanted to address the regulation of the neurotrophin brain-derived neurotrophic factor (BDNF) in serum and inflammatory skin of patients with chronic spontaneous urticaria in comparison to subjects with healthy skin. Methods Fifty adult patients with chronic spontaneous urticaria and 23 skin-healthy subjects were studied. Chronic spontaneous urticaria was defined as recurrent weals for more than 6 weeks. Autologous serum skin test was performed in all patients with chronic spontaneous urticaria and BDNF serum levels were analysed by enzyme immunoassay in all subjects. Furthermore, skin biopsies were taken from weals of eight patients with chronic spontaneous urticaria as well as from healthy skin of eight controls to evaluate the expression of BDNF and its receptors including tyrosine kinase (trk) B and pan-neurotrophin receptor p75(NTR) by immunohistochemistry. Results BDNF serum levels were detectable in all subjects studied. However, BDNF levels were significantly higher in patients with chronic spontaneous urticaria compared to non-atopic skin-healthy controls (P<0.001). Furthermore, epidermal and dermal expression of BDNF and epidermal expression of p75(NTR) was significantly higher in patients with chronic spontaneous urticaria compared with controls (P<0.05-0.001). There was no difference with regard to the expression of trkB between chronic spontaneous urticaria and controls and no difference in BDNF serum levels between autologous serum skin test-positive (n=23) and -negative (n=27) patients with chronic spontaneous urticaria. Conclusions and Clinical Relevance This study shows that BDNF is increased in serum and diseased skin of patients with chronic spontaneous urticaria, suggesting a role for neurotrophins in the pathophysiology of this chronic inflammatory skin disease. Further studies are needed to address the functional role of BDNF on key target effector cells in chronic spontaneous urticaria to establish new therapeutic implications. Cite this as: K. Rossing, N. Novak, S. Mommert, F. Pfab, M. Gehring, B. Wedi, A. Kapp and U. Raap, Clinical & Experimental Allergy, 2011 (41) 1392-1399.
机译：背景慢性自发性荨麻疹由许多直接和间接加重因素触发，包括自身反应性/自身免疫机制，感染，非过敏性和假性过敏性不耐受反应。然而，到目前为止，神经免疫机制在慢性自发性荨麻疹中的作用尚不清楚。目的因此，我们希望与健康皮肤受试者相比，解决慢性自发性荨麻疹患者血清和炎性皮肤中神经营养素脑源性神经营养因子（BDNF）的调节。方法对50例成人慢性自发性荨麻疹患者和23例皮肤健康受试者进行研究。慢性自发性荨麻疹定义为反复发作超过6周。对所有慢性自发性荨麻疹患者进行自体血清皮肤测试，并通过酶免疫法对所有受试者的BDNF血清水平进行分析。此外，从八名慢性自发性荨麻疹患者的饮食以及八名对照的健康皮肤中抽取皮肤活检样品，以通过以下方法评估BDNF及其受体的表达：BDNF及其受体，包括酪氨酸激酶（trk）B和泛神经营养素受体p75（NTR）。免疫组织化学。结果在所有研究对象中均可检测到BDNF血清水平。然而，与非过敏性皮肤健康对照组相比，慢性自发性荨麻疹患者的BDNF水平显着更高（P <0.001）。此外，与对照组相比，慢性自发性荨麻疹患者BDNF的表皮和真皮表达以及p75（NTR）的表皮表达显着更高（P <0.05-0.001）。慢性自发性荨麻疹患者与自发性荨麻疹患者的trkB表达无差异，自体血清皮肤试验阳性（n = 23）和-阴性（n = 27）患者的BDNF血清水平无差异。结论和临床意义这项研究表明，慢性自发性荨麻疹患者的血清和患病皮肤中BDNF升高，提示神经营养蛋白在这种慢性炎症性皮肤病的病理生理中具有重要作用。需要进一步的研究来解决BDNF在慢性自发性荨麻疹中关键靶标效应细胞上的功能，以建立新的治疗意义。引用为：K.Rossing，N.Novak，S.Mommert，F.Pfab，M.Gehring，B.Wedi，A.Kapp和U.Raap，《临床与实验过敏》，2011（41）1392-1399。

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