• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma.
【24h】

Plasma brain-derived neurotrophic factor levels are associated with clinical severity in school age children with asthma.

机译：在学龄期哮喘儿童中，血浆脑源性神经营养因子水平与临床严重程度相关。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

BACKGROUND: Asthma is characterized by chronic inflammation of the airways with significant changes in leucocyte trafficking, cellular activation and tissue remodelling. Brain-derived neurotrophic factor (BDNF) has been involved with asthma and allergic diseases but its role as a severity marker in paediatric asthma has not been clinically assessed. OBJECTIVES: To evaluate plasma BDNF and inflammatory markers in order to address their relationships with disease severity in children (6-15 years) with controlled persistent asthma. METHODS: Children with persistent asthma were selected and lung function and skin prick tests were performed in all patients. Plasma BDNF levels and various inflammatory markers (CCL3, CCL11, CCL22, CCL24, CXCL8, CXCL9, CXCL10, soluble TNF receptors) were assessed by ELISAs. RESULTS: Subjects with moderate and severe asthma had higher BDNF levels than mild asthma and controls (P<0.001). The chemokines studied and soluble TNF receptors did not differ between the studied groups. CONCLUSION AND CLINICAL RELEVANCE: Our results indicate BDNF as a potential biomarker for clinical severity in children with asthma.
机译：背景：哮喘的特征是气道慢性炎症，白细胞运输，细胞活化和组织重塑发生显着变化。脑源性神经营养因子（BDNF）与哮喘和过敏性疾病有关，但其在儿童哮喘中作为严重性指标的作用尚未得到临床评估。目的：评估血浆BDNF和炎性标志物，以解决他们与控制性持续性哮喘患儿（6-15岁）疾病严重程度的关系。方法：选择患有持续性哮喘的儿童，并对所有患者进行肺功能和皮肤点刺试验。通过ELISA评估血浆BDNF水平和各种炎性标志物（CCL3，CCL11，CCL22，CCL24，CXCL8，CXCL9，CXCL10，可溶性TNF受体）。结果：中度和重度哮喘患者的BDNF水平高于轻度哮喘和对照组（P <0.001）。研究组之间的趋化因子和可溶性TNF受体没有差异。结论和临床意义：我们的结果表明BDNF是哮喘儿童临床严重程度的潜在生物标志物。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号