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首页> 外文期刊>Clinical and experimental allergy : >The effect of allergic rhinitis on adenosine concentration in exhaled breath condensate.
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The effect of allergic rhinitis on adenosine concentration in exhaled breath condensate.

机译：过敏性鼻炎对呼出气冷凝物中腺苷浓度的影响。

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Background Patients with allergic rhinitis (AR) frequently develop asthma. This initiating inflammation in the lower airways may result in increased levels of inflammatory mediators such as adenosine in the exhaled breath. Objective We compared adenosine levels in exhaled breath condensate (EBC) and both exhaled and nasal nitric oxide (NO) levels of AR patients and healthy control subjects. We also tested whether inhalation through inflamed nasal cavity during EBC sampling influences adenosine concentrations in exhaled air. Methods Exhaled and nasal NO levels were measured and EBC samples (at oral inhalation) were collected from 27 patients and 15 healthy controls. EBC collection was repeated after 15 min with subjects inhaling through their nose. Adenosine was measured by HPLC and NO was determined by chemiluminescence. Results The concentration of EBC adenosine was higher in patients with AR than in healthy controls (12.4+/-1.3 nm vs. 6.5+/-0.7 nm, P=0.0019) and this was accompanied by an increase in the concentration of exhaled NO (10.2+/-1.3 ppb vs. 5.3+/-0.5 ppb; P=0.0099, respectively). No difference in nasal NO was detected. EBC adenosine concentration showed a significant positive correlation with the level of exhaled NO. In contrast to healthy control subjects, patients with rhinitis had higher levels of exhaled adenosine when inhaling via the nose instead of the mouth (17.7+/-2.8 nm, P=0.007). Conclusion When compared with healthy subjects, patients with AR exhibit an increased concentration of exhaled adenosine and a related increase in exhaled NO concentration. EBC adenosine is further increased when rhinitis patients inhale through their nose than via their mouth. Our data suggest that non-asthmatic patients with rhinitis may have subclinical inflammation in their lower airways.
机译：背景过敏性鼻炎（AR）的患者经常患哮喘。下呼吸道的这种起始炎症可能导致呼出气中炎症介质（例如腺苷）的水平增加。目的我们比较了AR患者和健康对照者的呼出气冷凝液（EBC）中的腺苷水平以及呼出和鼻中一氧化氮（NO）水平。我们还测试了在EBC采样期间通过发炎的鼻腔吸入是否会影响呼出空气中的腺苷浓度。方法测量27例患者和15例健康对照者的呼气和鼻腔NO含量，并收集EBC样品（口服吸入）。 15分钟后重复EBC收集，受试者通过鼻子吸入。用HPLC测定腺苷，用化学发光法测定NO。结果AR患者的EBC腺苷浓度高于健康对照组（12.4 +/- 1.3 nm对6.5 +/- 0.7 nm，P = 0.0019），同时呼出的NO浓度升高（ 10.2 +/- 1.3 ppb与5.3 +/- 0.5 ppb;分别为P = 0.0099）。未检测到鼻腔NO的差异。 EBC腺苷浓度与呼出NO水平呈显着正相关。与健康对照组相比，鼻炎患者通过鼻子而不是嘴吸入时呼出的腺苷水平较高（17.7 +/- 2.8 nm，P = 0.007）。结论与健康受试者相比，AR患者的呼出腺苷浓度升高，呼出NO浓度升高。当鼻炎患者通过鼻子而不是通过嘴吸入时，EBC腺苷进一步增加。我们的数据表明，非哮喘性鼻炎患者的下呼吸道可能存在亚临床炎症。

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