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首页> 外文期刊>Clinical and experimental allergy : >Treatment with chitin microparticles is protective against lung histopathology in a murine asthma model.
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Treatment with chitin microparticles is protective against lung histopathology in a murine asthma model.

机译：在小鼠哮喘模型中，用几丁质微粒进行的治疗可预防肺组织病理。

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摘要

Chitin, a natural polysaccharide extracted from shrimp, is a potent T and B cell adjuvant when delivered in the form of chitin microparticles and can shift a polarized T-helper type 2 (Th2) immune response towards a Th1 response. We investigated the beneficial effects of the intranasal application of chitin microparticles in newborn mice before and after the establishment of a model of allergic asthma. Mice were grouped as asthma (A), primary prevention (PP), treatment (T), primary prevention+treatment (PPT) and control (C) groups. All mice except controls were sensitized with ovalbumin intraperitoneally and challenged intratracheally to establish the asthma model. Mice in the PP and PPT groups received chitin microparticles intranasally during the newborn period before sensitization. Mice in the PPT and T groups received intranasal chitin microparticles after challenge. Airway histopathology was evaluated in all groups. All of the airway histopathologic parameters of small and medium-sized airways of the T and PPT groups were significantly ameliorated when compared with the asthma model group. In the large airways, thicknesses of basement membrane, epithelium and subepithelial smooth muscle layers of the PPT group and basement membrane thicknesses of the T group were also significantly lower compared with the asthma model group. Comparison of the PP group with the asthma model group revealed significantly reduced goblet cell numbers and significantly reduced epithelial and basement membrane thicknesses in small and medium airways, in addition to significantly reduced basement membrane thicknesses in the medium-sized airways. Intranasal application of microgram quantities of chitin microparticles had a beneficial effect in preventing and treating histopathologic changes in the airways of asthmatic mice.
机译：几丁质是一种从虾中提取的天然多糖，当以几丁质微粒的形式递送时，它是有效的T细胞和B细胞佐剂，可将极化的2型辅助T（Th2）免疫应答转变为Th1应答。在建立过敏性哮喘模型之前和之后，我们调查了几丁质微粒在新生小鼠中鼻内应用的有益作用。将小鼠分为哮喘（A），一级预防（PP），治疗（T），一级预防+治疗（PPT）和对照组（C）组。除对照组外，所有小鼠腹膜内用卵清蛋白致敏，并气管内攻击以建立哮喘模型。 PP和PPT组的小鼠在致敏前的新生儿期间经鼻内接受甲壳质微粒。攻击后，PPT和T组的小鼠接受了鼻内几丁质微粒。在所有组中评估气道组织病理学。与哮喘模型组相比，T和PPT组中小型气道的所有气道组织病理学参数均得到明显改善。在大气道中，与哮喘模型组相比，PPT组的基底膜，上皮和上皮下平滑肌层的厚度以及T组的基底膜厚度也显着降低。 PP组与哮喘模型组的比较显示，中型气道中的杯状细胞数量显着减少，中小气道中的上皮和基底膜厚度显着降低，此外，中型气道的基底膜厚度也明显降低。鼻内应用几克几丁质微粒对预防和治疗哮喘小鼠气道的组织病理学改变具有有益的作用。

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