• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >Airway epithelial barrier function regulates the pathogenesis of allergic asthma.
【24h】

Airway epithelial barrier function regulates the pathogenesis of allergic asthma.

机译：气道上皮屏障功能调节过敏性哮喘的发病机理。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

The integrity of the airway epithelium in patients with asthma is often disrupted, with loss of epithelial cell-cell contacts. Airway epithelial barrier dysfunction may have important implications for asthma, because structural epithelial barrier function is tightly interwoven with the ability of the epithelium to regulate the immune system. We propose that changes at the airway epithelial barrier play a central role in the sensitisation to allergens and pathogenesis of allergic asthma. Many of the recently identified susceptibility genes for asthma are expressed in airway epithelium. However, the exact mechanisms by which the expression of epithelial susceptibility genes translates into a functionally altered response to aeroallergens in asthma are still unknown. In this review, we will focus on the role of airway epithelial barrier function in the susceptibility to develop allergic asthma and discuss therapeutic strategies aimed at the epithelial barrier.
机译：哮喘患者气道上皮的完整性经常被破坏，失去上皮细胞之间的接触。气道上皮屏障功能障碍可能对哮喘有重要影响，因为结构上皮屏障功能与上皮调节免疫系统的能力紧密相关。我们建议气道上皮屏障的变化在变应性哮喘的致敏和致病机理中起着核心作用。最近发现的许多哮喘易感基因在气道上皮中表达。然而，哮喘中上皮敏感性基因的表达转化为对气变应原的功能改变的反应的确切机制仍是未知的。在这篇综述中，我们将重点关注气道上皮屏障功能在易感性哮喘发作中的作用，并讨论针对上皮屏障的治疗策略。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号