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首页> 外文期刊>Clinical and experimental allergy : >Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe.
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Inverse association of farm milk consumption with asthma and allergy in rural and suburban populations across Europe.

机译：欧洲农村和郊区人口的农场牛奶消费与哮喘和过敏症呈反相关关系。

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BACKGROUND: Dietary interventions as a means for atopy prevention attract great interest. Some studies in rural environments claimed an inverse association between consumption of farm-produced dairy products and the prevalence of allergic diseases, but current evidence is controversial. OBJECTIVE: To investigate whether consumption of farm-produced products is associated with a lower prevalence of asthma and allergy when compared with shop-purchased products. METHODS: Cross sectional multi-centre study (PARSIFAL) including 14,893 children aged 5-13 years from five European countries (2823 from farm families and 4606 attending Steiner Schools as well as 5440 farm reference and 2024 Steiner reference children). A detailed questionnaire including a dietary component was completed and allergen-specific IgE was measured in serum. RESULTS: Farm milk consumption ever in life showed a statistically significant inverse association with asthma: covariate adjusted odds ratio (aOR) 0.74 [95% confidence interval (CI) 0.61-0.88], rhinoconjunctivitis: aOR 0.56 (0.43-0.73) and sensitization to pollen and the food mix fx5 (cut-off level of >or=3.5 kU/L): aOR 0.67 (0.47-0.96) and aOR 0.42 (0.19-0.92), respectively, and sensitization to horse dander: aOR 0.50 (95% CI 0.28-0.87). The associations were observed in all four subpopulations and independent of farm-related co-exposures. Other farm-produced products were not independently related to any allergy-related health outcome. CONCLUSION: Our results indicate that consumption of farm milk may offer protection against asthma and allergy. A deepened understanding of the relevant protective components of farm milk and a better insight into the biological mechanisms underlying this association are warranted as a basis for the development of a safe product for prevention.
机译：背景：饮食干预作为预防特应性疾病的手段引起了极大的兴趣。在农村环境中的一些研究声称，农场生产的乳制品的消费与过敏性疾病的流行之间存在反比关系，但目前的证据存在争议。目的：调查与购买农产品相比，食用农产品是否与哮喘和过敏症的患病率较低有关。方法：横断面多中心研究（PARSIFAL）包括来自五个欧洲国家的14893名5-13岁的儿童（2823个农场家庭和4606个参加斯坦纳学校的学生以及5440个农场参考儿童和2024个斯坦纳参考儿童）。完成了包括饮食成分的详细问卷调查，并在血清中测量了过敏原特异性IgE。结果：生活中食用的牛奶与哮喘之间存在统计学上的显着负相关：协变量校正后的优势比（aOR）0.74 [95％置信区间（CI）0.61-0.88]，鼻结膜炎：aOR 0.56（0.43-0.73）和对花粉和食物混合物fx5（截止水平>或= 3.5 kU / L）：aOR 0.67（0.47-0.96）和aOR 0.42（0.19-0.92），对马皮屑的敏感性：aOR 0.50（95％ CI 0.28-0.87）。在所有四个亚人群中均观察到这种关联，并且与农场相关的共同暴露无关。其他农场生产的产品并不独立于任何与过敏相关的健康结果。结论：我们的研究结果表明，食用牛奶可能可以预防哮喘和过敏。有必要加深对牛奶的相关保护成分的了解，并更好地了解这种关联的生物学机制，以此作为开发安全预防产品的基础。

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