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首页> 外文期刊>Biochimica et biophysica acta. Molecular basis of disease: BBA >Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy
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Resveratrol supplementation affects bone acquisition and osteoporosis: Pre-clinical evidence toward translational diet therapy

机译：白藜芦醇补充剂会影响骨骼获取和骨质疏松症：转化饮食疗法的临床前证据

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摘要

Osteoporosis is a major public health issue that is expected to rise as the global population ages. Resveratrol (RES) is a plant polyphenol with various anti-aging properties. RES treatment of bone cells results in protective effects, but dose translation from in vitro studies to clinically relevant doses is limited since bioavailability is not taken into account. The aims of this review is to evaluate in vivo evidence for a role of RES supplementation in promoting bone health to reduced osteoporosis risk and potential mechanisms of action. Due to multiple actions on both osteoblasts and osteoclasts, RES has potential to attenuate bone loss resulting from different etiologies and pathologies. Several animal models have investigated the bone protective effects of RES supplementation. Ovariectomized rodent models of rapid bone loss due to estrogen-deficiency reported that RES supplementation improved bone mass and trabecular bone without stimulating other estrogen-sensitive tissues. RES supplementation prior to age-related bone loss was beneficial. The hindlimb unloaded rat model used to investigate bone loss due to mechanical unloading showed RES supplementation attenuated bone loss in old rats, but had inconsistent bone effects in mature rats. In growing rodents, RES increased longitudinal bone growth, but had no other effects on bone. In the absence of human clinical trials, evidence for a role of RES on bone heath relies on evidence generated by animal studies. A better understanding of efficacy, safety, and molecular mechanisms of RES on bone will contribute to the determination of dietary recommendations and therapies to reduce osteoporosis. This article is part of a Special Issue entitled: Resveratol: Challenges in translating pre-clinical findings to improved patient outcomes. (C) 2014 Elsevier B.V. All rights reserved.
机译：骨质疏松症是一个重大的公共卫生问题，随着全球人口的老龄化，预计该问题将会加剧。白藜芦醇（RES）是一种具有多种抗衰老特性的植物多酚。骨细胞的RES治疗可产生保护作用，但由于未考虑生物利用度，因此从体外研究到临床相关剂量的剂量转换受到限制。这篇综述的目的是评估补充RES在促进骨骼健康，降低骨质疏松症风险和潜在作用机制中的作用的体内证据。由于对成骨细胞和破骨细胞都有多种作用，RES具有减轻因不同病因和病理而导致的骨质流失的潜力。几种动物模型研究了补充RES的骨骼保护作用。由于雌激素缺乏引起的快速骨丢失的去卵巢啮齿动物模型报道，补充RES可以改善骨量和小梁骨，而不会刺激其他对雌激素敏感的组织。在与年龄有关的骨质流失之前补充RES是有益的。用于研究由于机械卸载造成的骨丢失的后肢卸载大鼠模型显示RES补充可减轻老年大鼠的骨丢失，但在成熟大鼠中具有不一致的骨效应。在生长的啮齿动物中，RES可以增加骨骼的纵向生长，但对骨骼没有其他影响。在没有人类临床试验的情况下，RES对骨骼健康的作用的证据依赖于动物研究产生的证据。更好地了解RES在骨骼上的功效，安全性和分子机制，将有助于确定减少骨质疏松症的饮食建议和疗法。本文是名为“白藜芦醇：将临床前发现转化为改善患者预后的挑战”的特刊的一部分。 （C）2014 Elsevier B.V.保留所有权利。

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