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首页> 外文期刊>Clinical and experimental allergy : >Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants.
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Clinical effects of kestose, a prebiotic oligosaccharide, on the treatment of atopic dermatitis in infants.

机译：益生元寡糖甲酚糖治疗婴儿异位性皮炎的临床效果。

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BACKGROUND: Oligosaccharides may have beneficial properties of the prevention of atopic dermatitis (AD). Kestose, a fructo-oligosaccharide, stimulates the activity of bifidobacteria. OBJECTIVE: To assess the clinical effect of kestose on the treatment of AD in infants. METHODS: A randomized, double-blind, placebo-controlled trial was carried out using 15 and 14 infants with AD in the kestose group and placebo groups, respectively. One to 2 g kestose and maltose were administered to the subjects in the kestose and placebo groups, respectively, everyday for 12 weeks. Clinical evaluations of AD using Severity Scoring of Atopic Dermatitis (SCORAD) and the enumeration of bifidobacteria in the feces using real-time PCR were performed at Weeks 0, 6, and 12. RESULTS: The medians of the SCORAD score were significantly lower in the kestose group than in the placebo group on both Week 6 (25.3 vs. 36.4; P=0.004) and Week 12 (19.5 vs. 37.5; P<0.001). No significant correlation was found between the improvement of the SCORAD score and the count of bifidobacteria. CONCLUSION: Kestose was found to exert a beneficial effect on the clinical symptoms in infants with AD. The mechanism how does kestose improve the symptoms of AD remains to be elucidated.
机译：背景：寡糖可能具有预防特应性皮炎（AD）的有益特性。果糖，低聚果糖，刺激双歧杆菌的活性。目的：评估甲酚在婴儿AD中的临床疗效。方法：进行了一项随机，双盲，安慰剂对照试验，分别在空腹组和安慰剂组中分别对15例和14例AD患儿进行了研究。在每天的12周中，每天分别将1至2 g的蔗糖和麦芽糖分别施用给蔗糖和安慰剂组的受试者。在第0、6和12周对特应性皮炎的严重程度评分（SCORAD）进行AD的临床评估，并使用实时PCR对粪便中双歧杆菌进行计数。结果：SCORAD评分的中位数明显低于对照组。在第6周（25.3 vs. 36.4; P = 0.004）和第12周（19.5 vs. 37.5; P <0.001）时，康斯坦糖组的服用率均高于安慰剂组。在SCORAD分数的改善和双歧杆菌计数之间未发现显着相关性。结论：发现甲酚对AD婴儿的临床症状具有有益作用。核糖如何改善AD症状的机制尚待阐明。

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