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Immunomodulating effects of endotoxin in mouse models of allergic asthma.

机译：内毒素在过敏性哮喘小鼠模型中的免疫调节作用。

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摘要

Endotoxin or lipopolysaccharide (LPS) is a cell wall component of Gram-negative bacteria. Like aeroallergens, LPS is ubiquitous in our living environment. Epidemiology studies in young children have found that LPS exposure at home is inversely correlated with the development of atopic diseases, thus the 'hygiene hypothesis' for allergic diseases. However, positive association has also been found between indoor LPS exposure and the development of wheezing or asthma in children. In humans, experimental exposure to LPS in the airways can cause inflammatory responses and lung function changes directly or modulate responses to allergens indirectly, particularly in those with asthma. In animal studies, experimental exposure to LPS has generated some conflicting, sometimes opposite, results in host responses to allergen stimulation. In this article, we will review recent advances in our understanding of the immunomodulating effects of LPS on allergen-induced responses and analyse some of the possible reasons for the inconsistent findings.
机译：内毒素或脂多糖（LPS）是革兰氏阴性细菌的细胞壁成分。像气敏原一样，LPS在我们的生活环境中无处不在。幼儿的流行病学研究发现，在家中暴露于LPS与特应性疾病的发展呈负相关，因此是过敏性疾病的“卫生假说”。但是，还发现室内LPS暴露与儿童喘息或哮喘的发展之间存在正相关。在人类中，气道中LPS的实验性暴露会直接引起炎症反应和肺功能改变，或间接调节对过敏原的反应，尤其是在哮喘患者中。在动物研究中，实验性暴露于LPS产生了一些相互矛盾的，有时是相反的结果，导致宿主对变应原刺激的反应。在本文中，我们将回顾我们对LPS对过敏原诱导的应答的免疫调节作用的理解的最新进展，并分析不一致结果的一些可能原因。

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