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The association of asthma, nasal allergies, and positive skin prick tests with obesity, leptin, and adiponectin

机译：哮喘，鼻过敏和皮肤点刺试验阳性与肥胖，瘦素和脂联素的关系

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Background: Cross-sectional and longitudinal reports show that obese adults have more asthma than non-obese adults. A proposed mechanism is via effects of adipokines (leptin and adiponectin) on the immune system. Objective: We wished to measure the associations of asthma and other atopic diseases with serum adipokine levels and to find whether the associations with asthma were strong enough to rule out the possibility that they are secondary to the association of fatness measures with asthma. Methods: The Global Asthma and Allergy Network of Excellence (GA2LEN) clinical follow-up survey is a clinical survey, embedded in a larger multi-centre cross-sectional postal survey, involving, with a case/control design, enrichment of the sample with subjects with asthma and chronic rhinosinusitis (CRS). We recorded serum leptin or adiponectin in 845 men and 1110 women in 15 centres and also anthropometric measures of fatness including body mass index and waist/hip ratio, current asthma, and specific skin prick and IgE sensitisation. We used inverse sampling-probability-weighted rank and regression statistics to measure population associations of disease outcomes with adipokines in males and females, adjusting for confounders (area, age, smoking history, and number of elder siblings) and also mutually adjusting associations with adipokines and fatness measures. Results: One thousand nine hundred and fifty-five subjects aged 16-77 years had information on leptin or adiponectin levels. Leptin and leptin/adiponectin ratio were positively associated with the level of asthma, especially in females (Somers' D of leptin by asthma score, 0.20; 95% CI, 0.08-0.30; P = 0.00079). These associations were attenuated after adjusting for confounders and became non-significant after additionally adjusting for fatness measures and multiple comparisons. Conclusions and Clinical Relevance: Asthma levels are positively associated with serum leptin. However, we cannot rule out the possibility that this association is secondary to associations of both with fatness measures.
机译：背景：横断面和纵向报告显示，肥胖成年人比非肥胖成年人患哮喘的比例更高。提出的机制是通过脂联素（瘦素和脂联素）对免疫系统的作用。目的：我们希望测量哮喘和其他特应性疾病与血清脂肪因子水平的关联，并寻找与哮喘的关联是否足够强，以排除它们是继肥胖措施与哮喘关联之后的可能性。方法：全球哮喘和过敏卓越网络（GA2LEN）临床随访调查是一项临床调查，嵌入在较大的多中心横断面邮政调查中，其中涉及病例/对照设计，包括患有哮喘和慢性鼻鼻窦炎（CRS）的受试者。我们在15个中心的845名男性和1110名女性中记录了血清瘦素或脂联素，还对人体肥胖进行了人体测量，包括体重指数和腰臀比，当前的哮喘以及特定的皮肤刺痛和IgE致敏性。我们使用了逆抽样概率加权的秩和回归统计数据来测量男性和女性中脂肪代谢因子与疾病结局的人群相关性，校正混杂因素（区域，年龄，吸烟史和年长的兄弟姐妹的数量），并且还相互调整了与脂肪代谢因子的相关性和肥胖措施。结果：195万名16-77岁的受试者掌握了瘦素或脂联素水平的信息。瘦素和瘦素/脂联素比值与哮喘水平呈正相关，特别是在女性中（瘦素的Somers'D哮喘评分，0.20; 95％CI，0.08-0.30; P = 0.00079）。在对混杂因素进行调整后，这些关联性减弱了，而对脂肪测量和多重比较进行了额外调整后，这些关联性变得不显着。结论和临床意义：哮喘水平与血清​​瘦素呈正相关。但是，我们不能排除这种关联是次于脂肪测量关联的可能性。

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