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Conception via in vitro fertilization and delivery by Caesarean section are associated with paediatric asthma incidence

机译：体外受精和剖腹产分娩与小儿哮喘的发生有关

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摘要

Background: The association between perinatal factors and asthma inception is under rigorous investigation. Nevertheless, evidence of a correlation between asthma, conception via in vitro fertilization (IVF) and delivery through Caesarean section (C-section) is inconclusive. Objective: We aimed to assess the relation of asthma incidence with IVF and C-section, after controlling for several potential confounding factors. Methods: Parent-reported wheeze in the last 12 months (current), wheeze ever, physician-diagnosed asthma, method of conception, and type of delivery were recorded from questionnaires filled in by the parents of 2016 Greek children aged 9-13, (the Healthy Growth Study population). Some perinatal data were recorded from children's medical records and others were reported by parents; anthropometric measurements were also conducted in children. Results: IVF was correlated with physician-diagnosed asthma (OR = 2.25; 95% CI = 1.11-4.56), but not with current/ever wheeze after adjustment for potential confounding factors. After adjustment, C-section was also associated with asthma (OR = 1.39; 95% CI = 1.04-1.87), but not with current/ever wheeze. When the association of both IVF and C-section with asthma was examined in the same multivariate logistic regression model, it was weakened to borderline significance (OR = 2.04; 95% CI = 1-4.15 and OR = 1.34; 95% CI = 1-1.81 respectively). Conclusions and Clinical Relevance: Conception via IVF and delivery by C-section may predispose children to future asthma development. Either variable could also exert a confounding effect on the link of the other to asthma; this may partially be accountable for inconsistencies in the findings of pertinent studies.
机译：背景：围产期因素与哮喘发作之间的关系正在严格研究中。然而，哮喘，通过体外受精（IVF）受孕和通过剖腹产（C-section）进行分娩之间没有关联的证据尚无定论。目的：在控制了一些潜在的混杂因素之后，我们旨在评估哮喘发生率与IVF和剖腹产的关系。方法：从2016年希腊9-13岁儿童父母填写的问卷中记录父母最近12个月报告的喘息（当前），曾经喘息，医生诊断的哮喘，受孕方法和分娩类型，健康成长研究人口）。一些围产期数据是从儿童的病历中记录的，其他则是由父母报告的;还对儿童进行了人体测量。结果：IVF与医生诊断的哮喘有关（OR = 2.25; 95％CI = 1.11-4.56），但与潜在的混杂因素调整后的当前/曾经喘息无关。调整后，剖腹产也与哮喘有关（OR = 1.39; 95％CI = 1.04-1.87），但与当前/曾经的喘息无关。当在同一多元Logistic回归模型中检查IVF和C形截面与哮喘的相关性时，IVF和C横断面与哮喘的相关性被减弱到临界意义（OR = 2.04; 95％CI = 1-4.15和OR = 1.34; 95％CI = 1 -1.81）。结论与临床意义：通过体外受精（IVF）进行受孕和剖腹产可能使儿童容易患上未来的哮喘。任一个变量也可能对另一个与哮喘的联系产生混淆作用。这可能部分归因于相关研究结果的不一致。

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