CD39(+) regulatory T cells attenuate allergic airway inflammation

Li P.; Gao Y.; Cao J.; Wang W.; Chen Y.; Zhang G.; Robson S. C.; Wu Y.; Yang J.

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CD39(+) regulatory T cells attenuate allergic airway inflammation

机译：CD39（+）调节性T细胞减轻过敏性气道炎症

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BackgroundThe suppressive mechanism of regulatory T cells (Tregs) has remained incompletely clarified. Recent studies found that CD39 expressed by Tregs may participate in the immunoregulatory role of Tregs. CD39-induced ATP hydrolysis and/or adenosine generation contribute to the suppressive mechanism of Tregs. Previous studies suggested that ATP is involved in allergic airway inflammation by acting on type 2 purinergic (P2) receptors, but the role of CD39 and CD39(+)Tregs in allergic airway inflammation has not been elaborated.

机译：背景调节性T细胞（Tregs）的抑制机制仍未完全阐明。最近的研究发现，Tregs表达的CD39可能参与Tregs的免疫调节作用。 CD39诱导的ATP水解和/或腺苷生成有助于Treg的抑制机制。先前的研究表明，ATP通过作用于2型嘌呤（P2）受体而参与过敏性气道炎症，但尚未阐明CD39和CD39（+）Tregs在过敏性气道炎症中的作用。

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《Clinical and experimental allergy :》 |2015年第6期|共12页
作者
Li P.; Gao Y.; Cao J.; Wang W.; Chen Y.; Zhang G.; Robson S. C.; Wu Y.; Yang J.;
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原文格式 PDF
正文语种 eng
中图分类医学免疫学;
关键词
adenosine; allergic asthma; ATP; CD39; regulatory T cells;

机译：腺苷;过敏性哮喘;ATP;CD39;调节性T细胞;

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1. CD39(+) regulatory T cells attenuate allergic airway inflammation [J] . Li P., Gao Y., Cao J., Clinical and experimental allergy : . 2015,第6期

机译：CD39（+）调节性T细胞减轻过敏性气道炎症
2. Regulatory T cells migrate to airways via CCR4 and attenuate the severity of airway allergic inflammation [J] . FaustinoL., DaFonsecaD.M., TakenakaM.C., The Journal of Immunology: Official Journal of the American Association of Immunologists . 2013,第6期

机译：调节性T细胞通过CCR4迁移至气道并减轻气道过敏性炎症的严重性
3. Cytotoxic T lymphocyte antigen 4 immunoglobulin modified dendritic cells attenuate allergic airway inflammation and hyperresponsiveness by regulating the development of T helper type 1 (Th1)/Th2 and Th2/regulatory T cell subsets in a murine model of asthma. [J] . Ying L, Fu Z, Luo J, Clinical and Experimental Immunology: An Official Journal of the British Society for Immunology . 2011,第1期

机译：细胞毒性T淋巴细胞抗原4免疫球蛋白修饰的树突状细胞通过调节哮喘小鼠模型中T辅助1型（Th1）/ Th2和Th2 /调节性T细胞亚群的发育，减轻了过敏性气道炎症和高反应性。
4. The Role of Histamine in Goblet Cell Hyperplasia in Allergic Airway Inflammation - A Study Using the HDC Knockout Mouse - [C] . H. M. Piao, K. Yamauchi, Y. Nakamura Asia Pacific Congress of Allergology and Clinical Immunology . 2004

机译：组胺在过敏气道炎症中戈尔特细胞增生中的作用 - 一种使用HDC敲除鼠标的研究 -
5. B and T lymphocyte attenuator and the termination of allergic airway inflammation [D] . Deppong, Christine Marie Neumann 2008

机译：B和T淋巴细胞减毒剂和过敏性气道炎症的终止
6. Attenuated allergic airway inflammation in Cd39 null mice [O] . Marco Idzko, C. Korcan Ayata, Tobias Müller, -1

机译：CD39含氟小鼠中的减毒过敏气道炎症
7. Regulatory T Cells Migrate to Airways via CCR4 and Attenuate the Severity of Airway Allergic Inflammation [O] . Faustino, Lucas, Fonseca, Denise Morais da, Takenaka, Maisa Carla Silveira, 2013

机译：调节性T细胞通过CCR4迁移至气道并减轻气道过敏性炎症的严重程度

CD39(+) regulatory T cells attenuate allergic airway inflammation

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