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首页> 外文期刊>Clinical and experimental allergy : >The efficacy of sublingual immunotherapy with Dermatophagoides farinae vaccine in a murine atopic dermatitis model
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The efficacy of sublingual immunotherapy with Dermatophagoides farinae vaccine in a murine atopic dermatitis model

机译：粉状皮肤癣菌疫苗舌下免疫疗法在小鼠特应性皮炎模型中的功效

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Background Sublingual immunotherapy (SLIT) is a potential treatment for house dust mite-induced atopic dermatitis (AD). However, the mechanisms of action are not clear.Objective To establish a mouse model of AD in order to study the effect and mechanisms of SLIT.Methods Mice were sensitized and subsequently challenged by repeated cutaneous application of Der f allergen extract. Sensitized mice were SLIT-treated with a Der f vaccine and analyzed for AD symptoms, histopathological and immunological parameters. This experiment was carried in the Laboratory Animal Center, Shanghai University of TCM.Repeated application of Der f extract caused rapid increase in dermatitis scores. Clinical findings (scratching behaviour, dermatitis and oedema) and histological symptoms (inflammatory cell infiltration) in this model were very similar to those in human AD. Serum total and Der f-specific IgE and IgG levels, and the expression level of T helper (Th)2 cytokine IL-5, IL-13; and Th1 cytokine IL-12 and IFN-?were elevated compared with the control mice. SLIT treatment of sensitized mice markedly reduced the clinical and histopathological symptoms and decreased both Th1 and Th2 cytokine levels
机译：背景舌下免疫疗法（SLIT）是治疗屋尘螨诱发的特应性皮炎（AD）的潜在疗法。然而，其作用机制尚不清楚。目的建立AD小鼠模型，以研究SLIT的作用和机制。方法致敏小鼠，随后经皮肤反复应用Der ferergen提取物攻击。致敏的小鼠用Der f疫苗进行SLIT处理，并分析AD症状，组织病理学和免疫学参数。该实验在上海中医药大学实验动物中心进行。Derf提取物的重复使用导致皮炎评分迅速增加。该模型的临床发现（抓挠行为，皮炎和水肿）和组织学症状（炎性细胞浸润）与人类AD非常相似。血清总和Der f特异性IgE和IgG水平，以及T辅助（Th）2细胞因子IL-5，IL-13的表达水平;与对照小鼠相比，Th1和Th1细胞因子IL-12和IFN-γ升高。 SLIT治疗致敏小鼠可显着降低临床和组织病理学症状，并降低Th1和Th2细胞因子水平

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