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首页> 外文期刊>Clinical and experimental allergy : >Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates.
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Early childhood wheezing symptoms in relation to plasma selenium in pregnant mothers and neonates.

机译：孕妇母亲和新生儿中与血浆硒有关的儿童早期喘息症状。

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Objective Reduced dietary selenium intake has been linked to the development of asthma. We have investigated whether childhood wheezing symptoms, and asthma up to the age of 5 years are associated with plasma selenium and erythrocyte glutathione peroxidase (GPx) concentrations in pregnant mothers and neonates. Methods Two thousand pregnant women were recruited and their 1924 singleton children followed up. Plasma selenium and erythrocyte GPx concentrations were measured in maternal blood during early pregnancy (12 weeks gestation) and in neonatal cord blood. Cohort children were followed up at 1, 2 and 5 years using a respiratory symptom questionnaire and at 5 years children were also invited for spirometry and skin-prick test (SPT). Maternal and neonatal plasma selenium and erythrocyte GPx were related to the childhood outcomes of wheezing, and asthma. Results At 2 years 1282 children were followed up. At 5 years symptom data were available for 1167 children, 700 children were SPT tested, and forced expiratory volume in 1 s (FEV(1)) was measured in 478. Maternal plasma selenium concentration during early pregnancy was inversely associated with wheezing (odds ratio per 10 mug/kg plasma selenium 0.86, 95% confidence interval 0.76-0.97), and consulting a doctor because of wheeze (0.79, 0.69-0.93) in the second year of life. Cord plasma selenium was also inversely associated with wheezing (0.67, 0.47-0.96), and consulting a doctor because of wheeze (0.62, 0.41-0.93) in the second year of life. By age 5 these associations had disappeared. Maternal and neonatal erythrocyte GPx concentrations were not associated with any childhood outcomes at 2 or 5 years. Conclusion The selenium status of mothers during early pregnancy, and neonates is associated with early childhood wheezing but not asthma or atopic sensitization, furthermore, this association is absent by the age of 5 years.
机译：目的减少饮食中硒的摄入与哮喘的发展有关。我们调查了儿童喘息症状和直至5岁的哮喘是否与孕妇和新生儿的血浆硒和红细胞谷胱甘肽过氧化物酶（GPx）浓度有关。方法招募了2000名孕妇，并对1924名单身儿童进行了随访。在怀孕初期（妊娠12周）和新生儿脐带血中测量母体血液中的血浆硒和红细胞GPx浓度。使用呼吸道症状问卷对队列儿童进行1、2和5年随访，并在5岁时邀请儿童进行肺活量测定和皮肤点刺试验（SPT）。母体和新生儿血浆硒和红细胞GPx与儿童喘息和哮喘的预后有关。结果2年后对1282名儿童进行了随访。在5年时可获得1167名儿童的症状数据，对700名儿童进行了SPT测试，并在478秒中测量了1 s的呼气量（FEV（1））。孕早期孕妇的血浆硒浓度与喘息呈负相关（比值比）每10杯/千克血浆硒0.86，95％置信区间0.76-0.97），并在第二年因喘鸣而咨询医生（0.79，0.69-0.93）。脐带血浆硒也与喘息呈负相关（0.67，0.47-0.96），并在生命的第二年因喘息（0.62，0.41-0.93）向医生咨询。到5岁时，这些关联就消失了。在2或5岁时，母亲和新生儿的红细胞GPx浓度与儿童期结局无关。结论母亲在妊娠早期和新生儿中的硒状态与儿童早期喘息有关，而与哮喘或过敏性过敏无关，而且，这种关联在5岁时就不存在。

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