• 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Clinical and experimental allergy : >The asthma-obesity link in childhood: open questions, complex evidence, a few answers only.
【24h】

The asthma-obesity link in childhood: open questions, complex evidence, a few answers only.

机译：儿童时期的肥胖症与肥胖症的联系：开放的问题，复杂的证据，仅提供一些答案。

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Obesity and asthma are public health priorities in developed countries. Genes which may contribute to the control of both conditions include those encoding for the beta2-adrenergic receptor, tumour necrosis factor-alpha (TNF-alpha) and the insulin-like growth factor 1 (IGF-1). Prospective studies consistently supported a link between obesity and reported wheezing or asthma diagnosis in children. However, there are still no clear explanations for such a link. On one hand, overweight asthmatic children may perceive their asthma as worse. On the other hand, atopic sensitization and bronchial hyper-reactivity do not explain the observed associations. After puberty, the association between asthma and obesity tends to be stronger in girls than in boys. It is conceivable that severe obesity in adolescent females may aggravate asthma through mechanisms different from those linking prepubertal obesity to unremitting asthma in males. Future studies should therefore address multiple age- and gender-specific hypotheses about the mechanisms that link obesity to asthma throughout childhood.
机译：肥胖和哮喘是发达国家的公共卫生重点。可能有助于控制两种疾病的基因包括编码β2-肾上腺素能受体，肿瘤坏死因子-α（TNF-α）和胰岛素样生长因子1（IGF-1）的基因。前瞻性研究始终支持肥胖与儿童气喘或哮喘的报告之间的联系。但是，对于这种链接仍然没有明确的解释。一方面，超重哮喘儿童可能会认为自己的哮喘病加重了。另一方面，特应性致敏和支气管高反应性不能解释所观察到的关联。青春期后，女孩的哮喘和肥胖之间的联系倾向于比男孩的联系更强。可以想象，青春期女性的严重肥胖可能通过不同于男性青春期肥胖与不缓解哮喘的机制加剧哮喘。因此，未来的研究应探讨关于肥胖与哮喘在整个童年时期相关的机制的多种年龄和性别特定假说。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号