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首页> 外文期刊>Clinical and experimental dermatology >Neonatal lupus erythematosus: factors which may lead to clinical disease in the foetus even in the absence of disease in the mother.
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Neonatal lupus erythematosus: factors which may lead to clinical disease in the foetus even in the absence of disease in the mother.

机译：新生儿红斑狼疮：即使母亲没有疾病也可能导致胎儿临床疾病的因素。

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Neonatal lupus erythematosus (NLE) occurs in neonates of mothers who, in almost all cases, have auto-antibodies to the SSA/Ro associated proteins, but who may have no clinical disease. However, only a small percentage of mothers with SSA/Ro antibodies have affected babies, predisposing factors specific to the foetus or neonate (i.e. HLA pattern) and/or fetal maternal interactions have been proposed to be important. We present a mother with a family history of autoimmune disease, but without clinical disease, whose baby developed cutaneous NLE. Autoantibody determinations as well as the HLA-DR/DQ were performed in the mother and baby. Factors other than the HLA-DR/DQ status of the mother appear to be important in determining whether or not the neonate will develop NLE. Auto-antibodies to endogenous antigens common to the mother, transiently expressed developmental antigens, and the isotype specificity of transferred antibodies may be important in determining disease in the baby.
机译：新生儿红斑狼疮（NLE）发生在母亲的新生儿中，这些母亲几乎在所有情况下均具有针对SSA / Ro相关蛋白的自身抗体，但可能没有临床疾病。但是，只有一小部分具有SSA / Ro抗体的母亲对婴儿产生了影响，对胎儿或新生儿特有的诱发因素（即HLA模式）和/或胎儿与母体的相互作用已被认为很重要。我们介绍了一位具有自身免疫性疾病家族史但没有临床疾病的母亲，其婴儿患了皮肤非LE。在母亲和婴儿中进行自身抗体测定以及HLA-DR / DQ。母亲的HLA-DR / DQ状况以外的因素对于确定新生儿是否会发展为非LE似乎很重要。母亲常见的内源性抗原的自身抗体，瞬时表达的发育性抗原以及转移抗体的同种型特异性在确定婴儿疾病中可能很重要。

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