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首页> 外文期刊>Clinical and experimental allergy : >Impact of native, heat-processed and encapsulated hazelnuts on the allergic response in hazelnut-allergic patients
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Impact of native, heat-processed and encapsulated hazelnuts on the allergic response in hazelnut-allergic patients

机译：天然，热处理和封装的榛子对榛子过敏患者的过敏反应的影响

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Background: Pollen-associated food allergy is common. However, systemic reactions or even life-threatening anaphylaxis are rare. Objective: The aim of this study was to investigate the clinical impact of native, heat-processed and encapsulated hazelnuts (HN) in patients with proven HN allergy. Methods: One hundred and thirty-two patients with a positive history of HN allergy were recruited. Sensitization was confirmed by a skin prick test (SPT) and sIgE against HN. After an HN-free diet, double-blind placebo-controlled challenges were performed with increasing amounts of native and roasted HN. A subset of patients were given HN capsules to circumvent the oral mucosa. Basophil activation was measured by flow cytometry before and after provocation but also ex vivo using native and roasted HN extracts. Results: Three groups of HN-allergic patients were identified depending on their clinical reaction pattern. The dosages by which allergic reactions were elicitated varied for native HN from 0.01 to 2.0 g, with a median of 0.1 g, for roasted HN from 0.01 to 10.0 g, with a median of 0.23 g, and for encapsulated HN from 0.1 to 3.0 g, with a median of 0.3 g. Accordingly, the SPT was more frequently positive and resulted in greater weal reactions if native HN was used. This finding was confirmed by ex vivo basophil activation showing that significantly higher allergen extract concentrations (roasted>native) were necessary to induce 50% basophil activation. Conclusion: Our data show that heat processing of HN reduces its allergenicity. SPT but also the basophil activation test can be used to determine the reactivity of an allergen extract.
机译：背景：与花粉有关的食物过敏很常见。但是，全身反应甚至危及生命的过敏反应很少见。目的：本研究的目的是调查天然，热加工和封装的榛子（HN）对已被证实患有HN过敏的患者的临床影响。方法：招募了132例HN变态反应阳性的患者。通过皮肤点刺试验（SPT）和针对HN的sIgE确认了敏化作用。不含HN的饮食后，通过增加天然和烤HN的量来进行双盲安慰剂对照挑战。为部分患者提供了HN胶囊以避免口腔粘膜。激发前后通过流式细胞术测量嗜碱性粒细胞的活化，但也可以使用天然和烤制的HN提取物离体测定。结果：根据他们的临床反应模式，确定了三组HN过敏患者。引发过敏反应的剂量对于天然HN从0.01到2.0 g，中位数为0.1 g;对于焙烤的HN从0.01到10.0 g，中位数：0.23 g;对于封装的HN，从0.1到3.0 g ，中位数为0.3克。因此，如果使用天然HN，则SPT更经常为阳性并导致更大的排毒反应。体外嗜碱细胞活化证实了这一发现，表明诱导50％嗜碱细胞活化需要显着更高的变应原提取物浓度（焙烧>天然）。结论：我们的数据表明，HN的热处理降低了其致敏性。 SPT以及嗜碱性粒细胞活化测试均可用于确定过敏原提取物的反应性。

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