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首页> 外文期刊>Clinical and experimental allergy : >Strain-specific immunomodulatory effects of Lactobacillus plantarum strains on birch-pollen-allergic subjects out of season.
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Strain-specific immunomodulatory effects of Lactobacillus plantarum strains on birch-pollen-allergic subjects out of season.

机译：植物乳杆菌菌株对桦树花粉过敏受试者的过时的菌株特异性免疫调节作用。

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BACKGROUND: Allergic diseases are increasing world-wide, and according to the hygiene hypothesis may be related to a decreased exposure to environmental bacteria. Probiotic bacteria are recognized for their immunomodulating properties, and may benefit allergy patients. In vitro studies reveal immunomodulatory effects that are strain dependent. Differential immunomodulatory in vitro capacities cannot be extrapolated directly to in vivo efficacy. Thus, in vitro screening should preferably be followed by a comparative analysis of the selected immunomodulatory strains in an in vivo setting. OBJECTIVE: We selected five Lactobacillus strains on their IL-10-inducing capacity, and evaluated the immunomodulatory properties in birch-pollen-allergic subjects outside the hayfever season, with a reduction of IL-13 as the primary outcome. METHODS: A double-blind, placebo-controlled parallel study was performed in which 62 subjects with a proven birch-pollen allergy consumed one of five different probiotic yoghurts containing four Lactobacillus plantarum strains and one Lactobacillus casei strain or a placebo yoghurt. Blood samples were collected at the start and after 4 weeks. Several immune parameters were determined in serum and peripheral blood mononuclear cell cultures (PBMC) derived from these subjects. Results A decrease in birch-pollen-specific IgE was found for four probiotic strains. L. casei Shirota reduced the number of CD16(+) /CD56(+) cells in peripheral blood mononuclear cells. For strain L. plantarum CBS125632, the decrease in IgE coincided with significant decreases in IL-5 and IL-13 production by alphaCD3/alphaCD28-stimulated PBMC cultures. CONCLUSION AND CLINICAL RELEVANCE: Subjects with seasonal allergy can be used to determine immunomodulatory responses outside the pollen season within a 4-week study period. L. plantarum CBS125632 decreased several immune markers related to allergy, and may have the potential to alleviate the severity of seasonal allergy symptoms.
机译：背景：过敏性疾病在全球范围内正在增加，根据卫生学假设，这可能与减少对环境细菌的接触有关。益生菌因其免疫调节特性而闻名，可能使过敏患者受益。体外研究揭示了依赖于菌株的免疫调节作用。体外免疫调节能力的差异不能直接推断到体内功效。因此，在体外筛选之后，优选应在体内设置后对所选免疫调节菌株进行比较分析。目的：我们选择了五种乳酸杆菌菌株，它们具有IL-10诱导能力，并评估了花粉热季节以外桦木花粉过敏受试者的免疫调节特性，其中IL-13的降低是主要结果。方法：进行了一项双盲，安慰剂对照的平行研究，其中62名桦树花粉过敏的受试者食用了5种不同的益生菌酸奶中的一种，其中含有4种植物乳杆菌菌株和1种干酪乳杆菌菌株或安慰剂酸奶。开始时和4周后收集血样。在源自这些受试者的血清和外周血单核细胞培养物（PBMC）中确定了几个免疫参数。结果发现四种益生菌菌株的桦花粉特异性IgE降低。 L. casei Shirota减少了外周血单个核细胞中CD16（+）/ CD56（+）细胞的数量。对于植物乳杆菌CBS125632，通过αCD3/αCD28刺激的PBMC培养物，IgE的降低与IL-5和IL-13产生的显着降低相吻合。结论和临床意义：季节性过敏的受试者可用于确定在4周研究期内花粉季节以外的免疫调节反应。植物乳杆菌CBS125632降低了与过敏相关的几种免疫标记，并且可能具有减轻季节性过敏症状的严重性的潜力。

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