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Sniffing out steroid responsiveness in asthma using an electronic nose

机译:使用电子鼻嗅探哮喘中的类固醇反应性

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摘要

This question is perhaps not so easy to answer. It is becoming increasingly evident that asthma is a complicated disease with different phenotype characteristics and different responses to common asthma medications [1, 2], and there is clearly a need to more efficiently characterize patients in the clinical setting. In traditional clinical practice, a combination of patient history and clinical findings, often recorded during repeated assessments, is commonly used. And albeit time-consuming, this approach is often successful. During the last decade, promising biomarkers such as fractional exhaled nitric oxide (FeNO) and sputum cell counts have emerged as additions to more traditional examinations such as lung function measurements and broncho dilator responses [3, 4]. In the featured study by van der Schee et al., [5] these methods were pitted against - and outmatched by - a novel device for exhaled breath analysis, the eNose.
机译:这个问题也许不是那么容易回答。越来越明显的是,哮喘是一种复杂的疾病,具有不同的表型特征和对常见哮喘药物的不同反应[1、2],并且显然需要在临床环境中更有效地表征患者。在传统的临床实践中,通常使用患者病史和临床发现的组合,通常在重复评估期间记录下来。尽管很耗时,但这种方法通常是成功的。在过去的十年中,有希望的生物标志物,如呼出气一氧化氮(FeNO)和痰细胞计数等,作为对肺功能测量和支气管扩张剂反应等更传统检查的补充[3,4]。在van der Schee等人的专题研究中,[5]这些方法与呼气呼吸分析的新型设备eNose相抵并相形见out。

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