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BSACI guideline for the diagnosis and management of cow's milk allergy.

机译:BSACI牛奶过敏诊断和管理指南。

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This guideline advises on the management of patients with cow's milk allergy. Cow's milk allergy presents in the first year of life with estimated population prevalence between 2% and 3%. The clinical manifestations of cow's milk allergy are very variable in type and severity making it the most difficult food allergy to diagnose. A careful age- and disease-specific history with relevant allergy tests including detection of milk-specific IgE (by skin prick test or serum assay), diagnostic elimination diet, and oral challenge will aid in diagnosis in most cases. Treatment is advice on cow's milk avoidance and suitable substitute milks. Cow's milk allergy often resolves. Reintroduction can be achieved by the graded exposure, either at home or supervised in hospital depending on severity, using a milk ladder. Where cow's milk allergy persists, novel treatment options may include oral tolerance induction, although most authors do not currently recommend it for routine clinical practice. Cow's milk allergy must be distinguished from primary lactose intolerance. This guideline was prepared by the Standards of Care Committee (SOCC) of the British Society for Allergy and Clinical Immunology (BSACI) and is intended for clinicians in secondary and tertiary care. The recommendations are evidence based, but where evidence is lacking the panel of experts in the committee reached consensus. Grades of recommendation are shown throughout. The document encompasses epidemiology, natural history, clinical presentations, diagnosis, and treatment.
机译:本指南建议对牛奶过敏的患者进行管理。牛奶过敏发生于生命的第一年,估计人口患病率在2%至3%之间。牛奶过敏的临床表现在类型和严重程度上变化很大,使其成为最难以诊断的食物过敏。仔细的针对特定年龄和疾病的病史以及相关的过敏试验,包括检测牛奶特异性IgE(通过皮肤点刺试验或血清测定),诊断性饮食消除和口服挑战,将在大多数情况下有助于诊断。治疗是避免牛乳和适当代乳的建议。牛奶过敏通常会解决。可以根据奶牛的严重程度,在家里或在医院的监督下,通过分级暴露来重新引入。在牛奶过敏持续存在的地方,新的治疗方法可能包括口服耐受诱导,尽管大多数作者目前不建议将其用于常规临床实践。牛奶过敏必须与原发性乳糖不耐症区分开。该指南是由英国过敏和临床免疫学会(BSACI)的护理标准委员会(SOCC)制定的,适用于二级和三级护理的临床医生。这些建议是基于证据的,但是在缺乏证据的情况下,委员会的专家小组达成了共识。整个推荐级别。该文件涵盖了流行病学,自然史,临床表现,诊断和治疗。

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