...
  • 主题
高级搜索  >
历史搜索 清空历史
首页> 外文期刊>Computerized Medical Imaging and Graphics: The Official Jounal of the Computerized Medical Imaging Society >MRI-3D ultrasound-X-ray image fusion with electromagnetic tracking for transendocardial therapeutic injections: In-vitro validation and in-vivo feasibility
【24h】

MRI-3D ultrasound-X-ray image fusion with electromagnetic tracking for transendocardial therapeutic injections: In-vitro validation and in-vivo feasibility

机译：MRI-3D超声-X射线图像融合与电磁跟踪，用于心内膜治疗性注射：体外验证和体内可行性

获取原文
获取原文并翻译 | 示例
           
页面导航
  • 摘要
  • 著录项
  • 相似文献
  • 相关主题

摘要

Myocardial infarction (MI) is one of the leading causes of death in the world. Small animal studies have shown that stem-cell therapy offers dramatic functional improvement post-MI. An endomyocardial catheter injection approach to therapeutic agent delivery has been proposed to improve efficacy through increased cell retention. Accurate targeting is critical for reaching areas of greatest therapeutic potential while avoiding a life-threatening myocardial perforation. Multimodal image fusion has been proposed as a way to improve these procedures by augmenting traditional intra-operative imaging modalities with high resolution pre-procedural images. Previous approaches have suffered from a lack of real-time tissue imaging and dependence on X-ray imaging to track devices, leading to increased ionizing radiation dose. In this paper, we present a new image fusion system for catheter-based targeted delivery of therapeutic agents. The system registers real-time 3D echocardiography, magnetic resonance, X-ray, and electromagnetic sensor tracking within a single flexible framework. All system calibrations and registrations were validated and found to have target registration errors less than 5 mm in the worst case. Injection accuracy was validated in a motion enabled cardiac injection phantom, where targeting accuracy ranged from 0.57 to 3.81 mm. Clinical feasibility was demonstrated with in-vivo swine experiments, where injections were successfully made into targeted regions of the heart.
机译：心肌梗塞（MI）是世界上主要的死亡原因之一。小动物研究表明，干细胞疗法可在心梗后提供显着的功能改善。已经提出了用于治疗剂递送的心内膜导管注射方法以通过增加的细胞保留来提高功效。准确靶向对于在避免威胁生命的心肌穿孔的同时达到最大治疗潜力至关重要。已经提出多模式图像融合作为通过用高分辨率的术前图像增强传统的术中成像模态来改善这些程序的方法。先前的方法缺乏实时的组织成像，并且依赖于X射线成像来跟踪设备，导致电离辐射剂量增加。在本文中，我们提出了一种新的图像融合系统，用于基于导管的治疗药物靶向输送。该系统在一个灵活的框架内记录实时3D超声心动图，磁共振，X射线和电磁传感器跟踪。所有系统校准和配准均经过验证，发现在最坏的情况下目标配准误差小于5毫米。注射精度已通过可运动的心脏注射体模进行了验证，其靶向精度范围为0.57至3.81 mm。猪体内实验证明了临床可行性，在该实验中，已成功地将药物注射到了心脏的目标区域。

著录项

相似文献

  • 外文文献
  • 中文文献
  • 专利
获取原文

客服邮箱：kefu@zhangqiaokeyan.com

京公网安备：11010802029741号 ICP备案号：京ICP备15016152号-6 六维联合信息科技 (北京) 有限公司©版权所有

  • 客服微信

  • 服务号