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首页> 外文期刊>Biomedicine & preventive nutrition >Thyroidectomy induced hepatic toxicity and possible amelioration by Ginkgo biloba leaf extract
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Thyroidectomy induced hepatic toxicity and possible amelioration by Ginkgo biloba leaf extract

机译：甲状腺切除术诱导的肝毒性和银杏叶提取物可能会改善

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The liver is a major target organ for thyroid hormone action and marked changes occur in liver functions in the case of hypo- or hyperthyroidism. This studied aimed at inverstigating the biochemical and histopathological changes in the liver after thyroidectomy and the ameliorating role of Ginkgo biloba leaf extract (GLE). A total of 50 male albino rats were equally divided into five groups; 1st to 3rd groups were control, sham operated and GLE groups while 4th group was thyroidectomized rat group and 5th group was treated thyrodectomized rat with GLE. Serum T3 and T4 levels after 3weeks of thyroidectomy was significantly decreased when compared with the control group, while TSH significantly increased when compared with the control group increased. Serum ALT, AST, ALP and GGT showed significant (P0.05) increase in thyroidectomized group when compared with control, sham operated and sham operated with GLE groups. On the one hand, treatment of thyroidectomized rats with GLE improved this increase in serum ALT, AST, ALP and GGT in thyroidectomized rat group. Liver sections of thyroidectomy group showed marked positive reaction and increase number of PCNA staining of hepatocyte nuclei. On the other hand, liver in treated of thyroidectomized rat with GLE group showed a marked reduction in the number of PCNA-positive nuclei when compared with sections in thyroidectomy group. Treatment of thyroidectomized rat with GLE improves the biochemical, histopathological and immunohistochemical alternations and the intensity of PCNA immunoreactive cells demonstrating the recovery of some injury.
机译：肝脏是甲状腺激素作用的主要靶器官，甲状腺功能减退或亢进时，肝功能发生明显变化。这项研究旨在阐明甲状腺切除术后肝脏的生化和组织病理学变化以及银杏叶提取物（GLE）的改善作用。总共50只雄性白化病大鼠被平均分为五组。第1至第3组为对照组，假手术组和GLE组，第4组为经甲状腺切除的大鼠组，第5组为经甲状腺切除的大鼠。与对照组相比，甲状腺切除3周后的血清T3和T4水平显着降低，而与对照组相比，TSH显着升高。与对照组，假手术组和假手术组相比，甲状腺切除组的血清ALT，AST，ALP和GGT显着增加（P <0.05）。一方面，用GLE治疗经甲状腺切除的大鼠改善了经甲状腺切除的大鼠组中血清ALT，AST，ALP和GGT的这种增加。甲状腺切除术组的肝脏切片显示出明显的阳性反应，肝细胞核的PCNA染色数量增加。另一方面，与甲状腺切除术组相比，GLE组治疗的甲状腺切除大鼠的肝脏显示出PCNA阳性核数目的明显减少。用GLE治疗甲状腺切除的大鼠改善了生化，组织病理学和免疫组化的改变，并改善了PCNA免疫反应细胞的强度，表明某些损伤已恢复。

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