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首页> 外文期刊>Biochemistry >Comparative models for human apolipoprotein a-I bound to lipid in discoidal high-density lipoprotein particles.
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Comparative models for human apolipoprotein a-I bound to lipid in discoidal high-density lipoprotein particles.

机译：盘状高密度脂蛋白颗粒中与脂质结合的人载脂蛋白a-I的比较模型。

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摘要

We have constructed a series of models for apolipoprotein A-I (apo A-I) bound to discoidal high-density lipoprotein (HDL) particles, based upon the molecular belt model [Segrest, J. P., et al. (1999) J. Biol. Chem. 274, 31755-31758] and helical hairpin models [Rogers, D. P., et al. (1998) Biochemistry 37, 11714-11725], and compared these with picket fence models [Phillips, J. C., et al. (1997) Biophys. J. 73, 2337-2346]. Molecular belt models for discoidal HDL particles with differing diameters are presented, illustrating that the belt model can explain the discrete changes in HDL particle size observed experimentally. Hairpin models are discussed for the binding of apo A-I to discoidal HDL particles with diameters identical to those for the molecular belt model. Two models are presented for the binding of three monomers of apo A-I to a 150 A diameter discoidal HDL particle. In one model, two monomers of apo A-I bind to the exterior of the HDL particle in an antiparallel belt, with a third monomer of apo A-I bound to the disk in a hairpin conformation. In the second model, all three monomers of apo A-I are bound to the discoidal HDL particle in a hairpin conformation. Previously published experimental data for each model are reviewed, with FRET favoring either the belt or hairpin models over the picket fence models for HDL particles with diameters of 105 A. Naturally occurring mutations appear to favor the belt model for the 105 A particles, while the 150 A HDL particles favor the presence of at least one hairpin.
机译：我们基于分子带模型[Segrest，J.P.，et al。，J.Pharm.Sci。，1992，8，5，4]，构建了与盘状高密度脂蛋白（HDL）颗粒结合的载脂蛋白A-1（apo A-1）的一系列模型。 （1999）生物化学杂志。化学274，31755-31758]和螺旋发夹模型[Rogers，D. P.等人。 （1998）Biochemistry 37，11714-11725]，并将其与栅栏模型进行比较[Phillips，J. C.，等人。 （1997）生物物理。 J. 73，2337-2346]。提出了具有不同直径的盘状HDL颗粒的分子带模型，表明该带模型可以解释实验观察到的HDL粒度的离散变化。讨论了发夹模型，用于将载脂蛋白A-I与直径与分子带模型直径相同的盘状HDL颗粒结合。提出了两种模型，用于将载脂蛋白A-1的三种单体与直径为150 A的盘状HDL颗粒结合。在一个模型中，载脂蛋白A-1的两个单体在反平行带中结合到HDL颗粒的外部，载脂蛋白A-1的第三种单体以发夹结构结合到盘上。在第二个模型中，载脂蛋白A-I的所有三个单体都以发夹状构象结合到盘状HDL颗粒上。审查了每个模型的先前发布的实验数据，对于直径为105 A的HDL颗粒，FRET偏爱于带栅或发夹模型而不是纠偏栅栏模型。自然发生的突变似乎偏向于105 A颗粒的带模型。 150 A HDL颗粒有利于至少存在一个发夹。

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