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首页> 外文期刊>Biochemistry >Model for a Helical Bundle Channel Based on the High-Resolution Crystal Structure of Trichotoxin_A50E.
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Model for a Helical Bundle Channel Based on the High-Resolution Crystal Structure of Trichotoxin_A50E.

机译：基于Trichotoxin_A50E的高分辨率晶体结构的螺旋束通道模型。

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摘要

Trichotoxin_A50E is an 18-residue peptaibol antibiotic which forms multimeric transmembrane channels through self-association. The crystal structure of trichotoxin has been determined at a resolution of 0.9 A. The trichotoxin sequence contains nine helix-promoting Aib residues, which contribute to the formation of an entirely helical structure that has a central bend of 8-10 degrees located between residues 10-13. Trichotoxin is the first solved structure of the peptaibol family that is all alpha-helix as opposed to containing part or all 3(10)-helix. Gln residues in positions 6 and 17 produce a polar face, and are proposed to form the channel lumen. An octameric model channel has been constructed from the crystal structure. It has a central pore of approximately 4-5 A radius, a size sufficient to enable transport of ions, with a constricted region at one end, formed by a ring of Gln6 residues. Electrostatic calculations are consistent with it being a cationic channel.
机译：Trichotoxin_A50E是一种18个残基的肽醇抗生素，可通过自缔合形成多聚体跨膜通道。滴虫毒素的晶体结构已在0.9 A的分辨率下测定。滴虫毒素序列包含9个螺旋促进Aib残基，这些残基有助于形成一个完整的螺旋结构，其中心弯曲为8-10度，位于残基10之间。 -13。天花毒素是肽醇家族中第一个已解析的结构，它是全α-螺旋，而不是包含部分或全部3（10）-螺旋。 6和17位的Gln残基产生极性面，并建议形成通道内腔。已从晶体结构构建了八位模型通道。它具有大约4-5 A半径的中心孔，其大小足以实现离子的运输，一端具有一个由Gln6残基环形成的狭窄区域。静电计算与它是阳离子通道是一致的。

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