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Pericyclic Reactions Catalyzed by Chorismate-Utilizing Enzymes

机译：分支酸酯利用酶催化的周环反应

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摘要

One of the fundamental questions of enzymology is how catalytic power is derived. This review focuses on recent developments in the structure?function relationships of chorismate-utilizing enzymes involved in siderophore biosynthesis to provide insight into the biocatalysis of pericyclic reactions. Specifically, salicylate synthesis by the two-enzyme pathway in Pseudomonas aeruginosa is examined. The isochorismate-pyruvate lyase is discussed in the context of its homologues, the chorismate mutases, and the isochorismate synthase is compared to its homologues in the MST family (menaquinone, siderophore, or tryptophan biosynthesis) of enzymes. The tentative conclusion is that the activities observed cannot be reconciled by inspection of the active site participants alone. Instead, individual activities must arise from unique dynamic properties of each enzyme that are tuned to promote specific chemistries.
机译：酶学的基本问题之一是如何获得催化能力。这篇综述着重于参与铁载体生物合成的利用分支酸利用酶的结构-功能关系的最新进展，以提供对周环反应的生物催化的见解。具体而言，检查了铜绿假单胞菌中通过两种酶途径的水杨酸酯合成。在其同系物，分支酸变位酶的背景下讨论了异高辛酸-丙酮酸裂合酶，并将异麦索糖酸合酶与其在MST家族中的同系物（甲萘醌，铁载体或色氨酸生物合成）进行了比较。初步的结论是，观察到的活动不能仅通过对活动现场参与者的检查进行核对。取而代之的是，必须通过调整每种酶的独特动态特性来促进其个体活动，这些动态特性经过调整可以促进特定的化学反应。

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