Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription

Kyoko L. Yap; Ming-Ming Zhou

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Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription

机译：基因转录中色域识别赖氨酸甲基化的结构和机制

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Histone methylation recognition is accomplished by a number of evolutionarily conserved protein domains, including those belonging to the methylated lysinebinding Royal family of structural folds. One well-known member of the Royal family, the chromodomain, is found in the HP1/chromobox and CHD subfamilies of proteins, in addition to a small number of other proteins that are involved in chromatin remodeling and gene transcriptional silencing. Here we discuss the structure and function of the chromodomain within these proteins as methylated histone lysine binders and how the functions of these chromodomains can be modulated by additional post-translational modifications or binding to nucleic acids.

机译：组蛋白甲基化识别是通过许多进化保守的蛋白质结构域实现的，包括那些属于结构折叠的甲基化赖氨酸结合皇家家族的结构域。在HP1 / chromobox和CHD的蛋白质亚家族中发现了Royal家族的一个著名成员，即chromodomain，此外还有少量其他与染色质重塑和基因转录沉默有关的蛋白质。在这里，我们讨论了这些蛋白质中作为甲基化组蛋白赖氨酸结合剂的染色体结构域的结构和功能，以及如何通过额外的翻译后修饰或与核酸的结合来调节这些染色体结构域的功能。

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《Biochemistry》 |2011年第12期|共15页
作者
Kyoko L. Yap; Ming-Ming Zhou;
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正文语种 eng
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Structure; Mechanisms; Gene Transcription;

机译：结构;机制;基因转录;

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1. Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription [J] . Kyoko L. Yap and Ming-Ming Zhou Biochemistry . 2011,第12期

机译：基因转录中色域识别赖氨酸甲基化的结构和机制
2. Mechanism of product specificity of AdoMet methylation catalyzed by lysine methyltransferases: Transcriptional factor p53 methylation by histone lysine methyltransferase SET7/9 [J] . Zhang XD, Bruice TC Biochemistry . 2008,第9期

机译：赖氨酸甲基转移酶催化AdoMet甲基化产物特异性的机理：组蛋白赖氨酸甲基转移酶SET7 / 9对转录因子p53甲基化的影响
3. Towards a Molecular Understanding of the Silencing of Transcription by Heterochromatin: Methylation of Histone H3 Lysine 9 Creates a Binding Site for HP1 Proteins Selective Recognition of Methylated Lysine 9 on Histone H3 by the HP1 Chromo Domain Rol [J] . M. Lachner, D. OCarroll, S. Rea, Chemtracts . 2001,第10期

机译：对通过异染色质沉默转录的分子理解：组蛋白H3赖氨酸9的甲基化为HP1蛋白形成结合位点通过组蛋白H1色域Rol对组蛋白H3的甲基化赖氨酸9进行选择性识别。
4. Complete Trimethylation of Histone Lysine Residues and its Application to the Quantitation of Lysine Methylation Using Mass Spectrometry [C] . Steven Toth, Anthony Berardinelli, Wendell P. Griffith ASMS Conference on Mass Spectrometry and Allied Topics . 2014

机译：通过质谱法将组蛋白赖氨酸残基的完全三甲基化及其应用于赖氨酸甲基化定量
5. Mechanisms and Functional Implications of Histone Methyl-Lysine Recognition by Chromodomains [D] . Blus, Bartlomiej Jan 2011

机译：色域识别组蛋白甲基赖氨酸的机制和功能意义
6. Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription [O] . Kyoko L. Yap, Ming-Ming Zhou -1

机译：结构和用染色质基因转录赖氨酸甲基识别机制
7. Two distinct repressive mechanisms for histone 3 lysine 4 methylation through promoting 3'-end antisense transcription. [O] . Margaritis, Thanasis, Oreal, Vincent, Brabers, Nathalie, 2012

机译：组蛋白3赖氨酸4甲基化通过促进3'端反义转录的两个不同的阻抑机制。

Structure and Mechanisms of Lysine Methylation Recognition by the Chromodomain in Gene Transcription

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