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首页> 外文期刊>Biochemistry >Stability of Heterochiral Hybrid Membrane Made of Bacterial sn-G3P Lipids and Archaeal sn-G1P Lipids
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Stability of Heterochiral Hybrid Membrane Made of Bacterial sn-G3P Lipids and Archaeal sn-G1P Lipids

机译：细菌sn-G3P脂质和古细菌sn-G1P脂质制成的杂合杂化膜的稳定性

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摘要

The structure of membrane lipids in Archaea is different from those of Bacteria and Eucarya in many ways including the chirality of the glycerol backbone. Until now, heterochiral membranes were believed to be unstable; thus, no cellular organism could have existed before the separation of the groups of life. In this study, we tested the formation of heterochiral hybrid membrane made of Bacterial sn-glycerol-3-phosphate-type polar lipid and Archaeal sn-glycerol-1-phosphate-type polar lipid using the fluorescence probe. The stability of the hybrid liposomes made of phosphatidylethanolamines or phosphatidylcholines or polar lipids of thermophilic Bacteria and polar lipids of Archaea were investigated. The hybrid liposomes are all stable compared with homochiral liposome made of dimyristoylphosphatidylethanolamine and dipalmitoylphosphatidylcholine. However, the stability was drastically changed with increasing carbon chain length. Accordingly, "chirality" may not be but chain length is important. From these results, we suggest that the heterochiral hybrid membrane could be used as the membrane lipid for the last universal common ancestor the emergence of Archaea and Bacteria.
机译：古细菌中膜脂的结构在许多方面与细菌和真核生物不同，包括甘油骨架的手性。到目前为止，人们认为杂手性膜是不稳定的。因此，在生命类别分离之前就不会存在细胞生物。在这项研究中，我们使用荧光探针测试了由细菌sn-甘油-3-磷酸酯型极性脂质和Archaeal sn-甘油-1-磷酸酯型极性脂质组成的杂手性杂合膜的形成。研究了由磷脂酰乙醇胺或磷脂酰胆碱或嗜热细菌的极性脂质和古细菌的极性脂质制成的杂化脂质体的稳定性。与由二肉豆蔻酰基磷脂酰乙醇胺和二棕榈酰磷脂酰胆碱制成的同手性脂质体相比，杂化脂质体都稳定。但是，稳定性随着碳链长度的增加而急剧变化。因此，“手性”可能不是，但是链长很重要。从这些结果，我们建议杂手性杂种膜可以用作古细菌和细菌的最后通用祖先的膜脂质。

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