Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis

Li H.; Outten C.E.

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Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis

机译：单硫醇CGFS戊二醛毒素和BolA样蛋白：[2Fe-2S]铁稳态中的结合伙伴

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Monothiol glutaredoxins (Grxs) with a signature CGFS active site and BolA-like proteins have recently emerged as novel players in iron homeostasis. Elegant genetic and biochemical studies examining the functional and physical interactions of CGFS Grxs in the fungi Saccharomyces cerevisiae and Schizosaccharomyces pombe have unveiled their essential roles in intracellular iron signaling, iron trafficking, and the maturation of Fe-S cluster proteins. Biophysical and biochemical analyses of the [2Fe-2S] bridging interaction between CGFS Grxs and a BolA-like protein in S. cerevisiae provided the first molecular-level understanding of the iron regulation mechanism in this model eukaryote and established the ubiquitous CGFS Grxs and BolA-like proteins as novel Fe-S cluster-binding regulatory partners. Parallel studies focused on Escherichia coli and human homologues for CGFS Grxs and BolA-like proteins have supported the studies in yeast and provided additional clues about their involvement in cellular iron metabolism. Herein, we review recent progress in uncovering the cellular and molecular mechanisms by which CGFS Grxs and BolA-like proteins help regulate iron metabolism in both eukaryotic and prokaryotic organisms. (Figure Presented).

机译：具有标志性CGFS活性位点和BolA样蛋白的一硫醇戊二醛毒素（Grxs）最近已成为铁稳态中的新角色。优雅的遗传和生化研究检查了酿酒酵母和粟酒裂殖酵母中CGFS Grxs的功能和物理相互作用，揭示了它们在细胞内铁信号传导，铁运输和Fe-S簇蛋白成熟中的重要作用。酿酒酵母中CGFS Grxs与BolA样蛋白之间[2Fe-2S]桥接相互作用的生物物理和生化分析提供了对该模型真核生物中铁调节机制的第一个分子水平的理解，并建立了无处不在的CGFS Grxs和BolA类蛋白作为新型Fe-S簇结合调节伴侣。针对CGFS Grxs和BolA样蛋白的大肠杆菌和人类同源物的平行研究支持了酵母中的研究，并提供了有关它们参与细胞铁代谢的其他线索。本文中，我们回顾了发现CGFS Grxs和BolA样蛋白通过细胞和分子机制帮助调节真核生物和原核生物中铁代谢的最新进展。（如图所示）。

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《Biochemistry》 |2012年第22期|共13页
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Li H.; Outten C.E.;
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1. Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis [J] . Li H., Outten C.E. Biochemistry . 2012,第22期

机译：单硫醇CGFS戊二醛毒素和BolA样蛋白：[2Fe-2S]铁稳态中的结合伙伴
2. Two novel monothiol glutaredoxins from Saccharomyces cerevisiae provide further insight into iron-sulfur cluster binding, oligomerization, and enzymatic activity of glutaredoxins [J] . Mesecke N, Mittler S, Eckers E, Biochemistry . 2008,第5期

机译：来自酿酒酵母的两种新颖的单硫醇戊二醛毒素提供了对铁硫簇结合，寡聚和戊二醛酶活性的进一步了解
3. Multi-domain CGFS-type glutaredoxin Grx4 regulates iron homeostasis via direct interaction with a repressor Fep1 in fission yeast. [J] . Kim KD, Kim HJ, Lee KC, Biochemical and Biophysical Research Communications . 2011,第4期

机译：CGFS型多域谷胱甘肽毒素Grx4通过与裂变酵母中的阻遏物Fep1直接相互作用来调节铁稳态。
4. NMR STUDIES OF POPLAR GLUTAERDOXIN C1——A CONNECTION BETWEEN GLUTAREDOXIN AND IRON-SULFUR PROTEIN [C] . . 2005

机译：杨树谷蛋白X1的核磁共振研究-谷胱甘肽氧还蛋白与铁硫蛋白的关系
5. Characterization and functional studies of iron-sulfur cluster binding in monothiol glutaredoxin-BolA complexes regulating iron homeostasis [D] . Li, Haoran 2011

机译：调节铁稳态的单硫醇戊二醛-BolA复合物中铁-硫簇结合的表征和功能研究
6. Monothiol CGFS Glutaredoxins and BolA-like Proteins: 2Fe-2S Binding Partners in Iron Homeostasis [O] . Haoran Li, Caryn E. Outten -1

机译：单硫醇CGFs谷氧还蛋白和拨拉样蛋白：的2Fe-2s在铁稳态结合伴侣
7. CGFS-Type Monothiol Glutaredoxins from the Cyanobacterium Synechocystis PCC6803 and Other Evolutionary Distant Model Organisms Possess a Glutathione-Ligated 2Fe-2S Cluster [O] . -1

机译：CGFS型从肌腱杆菌和其他进化远处模型生物中的半藻醇类氨基甲蛋白具有谷胱甘肽连接的2FE-2S簇

Monothiol CGFS glutaredoxins and BolA-like proteins: [2Fe-2S] binding partners in iron homeostasis

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