Homocysteine Is Biosynthesized from Aspartate Semialdehyde and Hydrogen Sulfide in Methanogenic Archaea

Allen Kylie D.; Miller Danielle V.; Rauch Benjamin J.; Perona John J.; White Robert H.

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Homocysteine Is Biosynthesized from Aspartate Semialdehyde and Hydrogen Sulfide in Methanogenic Archaea

机译：同型半胱氨酸由产甲烷的古细菌中的天冬氨酸半醛和硫化氢生物合成。

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The biosynthetic route for homocysteine, intermediate in methionine biosynthesis; is unknown in some methanogenic archaea because homologues of the canonical required genes cannot be identified. Here we demonstrate that Methanocaldococcus jannaschii can biosynthesize homocysteine from aspartate semialdehyde and hydrogen sulfide. Additionally, we confirm the genes involved in this new pathway in Methanosarcina acetivorans. A possible series of reactions in which a thioaldehyde is formed and then reduced to a thiol are proposed. This represents a novel route for the biosynthesis of homocysteine and exemplifies unique aspects of Sulfur chemistry occurring in prebiotic environments and in early life forms.

机译：高半胱氨酸的生物合成途径，蛋氨酸生物合成的中间产物;在某些产甲烷的古细菌中未知，因为无法确定所需的规范基因的同源物。在这里，我们证明詹纳氏甲烷球菌可以从天冬氨酸半醛和硫化氢生物合成高半胱氨酸。此外，我们确认了乙草甲烷菌中这个新途径的相关基因。提出了一系列可能的反应，其中形成硫醛然后还原为硫醇。这代表了高半胱氨酸生物合成的新途径，并举例说明了在益生元环境和早期生命形式中发生的硫化学的独特方面。

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《Biochemistry》 |2015年第20期|共4页
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Allen Kylie D.; Miller Danielle V.; Rauch Benjamin J.; Perona John J.; White Robert H.;
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1. Homocysteine Is Biosynthesized from Aspartate Semialdehyde and Hydrogen Sulfide in Methanogenic Archaea [J] . Allen Kylie D., Miller Danielle V., Rauch Benjamin J., Biochemistry . 2015,第20期

机译：同型半胱氨酸由产甲烷的古细菌中的天冬氨酸半醛和硫化氢生物合成。
2. Structure of aspartate-beta-semialdehyde dehydrogenase from Escherichia coli, a key enzyme in the aspartate family of amino acid biosynthesis. [J] . Hadfield A, Kryger G, Ouyang J, Journal of Molecular Biology . 1999,第4期

机译：来自大肠杆菌的天冬氨酸-β-半醛脱氢酶的结构，天冬氨酸氨基酸生物合成中的关键酶。
3. The exchange activities of [Fe] hydrogenase (iron-sulfur-cluster-free hydrogenase) from methanogenic archaea in comparison with the exchange activities of [FeFe] and [NiFe] hydrogenases [J] . Vogt S, Lyon EJ, Shima S, Journal of biological inorganic chemistry: JBIC: a publication of the Society of Biological Inorganic Chemistry . 2008,第1期

机译：与[FeFe]和[NiFe]氢化酶的交换活性相比，产甲烷古菌中的[Fe]氢化酶（无铁硫簇的氢化酶）的交换活性
4. Biological syngas methanation via immobilized methanogenic archaea on biochar [C] . Sebastian Schwede, Florian Bruchmann, Eva Thorin International Conference on Applied Energy . 2017

机译：通过固定化甲状腺素对生物炭的生物合成气甲烷化
5. Species diversity in the structure and mechanism of aspartokinase and aspartate-beta-semialdehyde dehydrogenase: Two essential enzymes in aspartate metabolism [D] . Faehnle, Christopher R. 2006

机译：天冬氨酸激酶和天冬氨酸-β-半醛脱氢酶的结构和机理中的物种多样性：天冬氨酸代谢中的两种必需酶
6. The exchange activities of Fe hydrogenase (iron–sulfur-cluster-free hydrogenase) from methanogenic archaea in comparison with the exchange activities of FeFe and NiFe hydrogenases [O] . Sonja Vogt, Erica J. Lyon, Seigo Shima, -1

机译：产甲烷古菌中Fe氢化酶（无铁硫簇的氢化酶）的交换活性与FeFe和NiFe氢化酶的交换活性相比
7. The exchange activities of Fe hydrogenase (iron–sulfur-cluster-free hydrogenase) from methanogenic archaea in comparison with the exchange activities of FeFe and NiFe hydrogenases [O] . Sonja Vogt, Erica J. Lyon, Seigo Shima, 2007

机译：产甲烷古菌中Fe氢化酶（无铁硫簇的氢化酶）的交换活性与FeFe和NiFe氢化酶的交换活性相比

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Homocysteine Is Biosynthesized from Aspartate Semialdehyde and Hydrogen Sulfide in Methanogenic Archaea

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