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首页> 外文期刊>Biomaterials >The relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour.
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The relative influence of the topography and chemistry of TiAl6V4 surfaces on osteoblastic cell behaviour.

机译：TiAl6V4表面的形貌和化学性质对成骨细胞行为的相对影响。

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摘要

Proliferation and adhesion of mouse (MC3T3-E1) osteoblastic cells and primary human osteoblastic cells were carried out on Ti6Al4V titanium alloy samples with varied surface roughnesses. Mechanically or manually polished surfaces were prepared to produce respectively non-oriented or oriented residual polishing grooves. Sand-blasted surfaces were prepared using 500 microm or 3 mm alumina particles. Surface roughness parameters showed a negative correlation in comparison to proliferation and adhesion parameters. X-ray microprobe chemical surface microanalysis showed complete disturbance of the surface element composition of the Ti6Al4V alloy following sand-blasting treatment. An AlOx-enriched layer was observed on sample surfaces. This may lead to the suspicion that the concomittant effect of surface roughness amplitude and AlOx surface concentration has an effect on osteoblastic cell proliferation and adhesion. These findings show the significance of chemical surface analysis after any surface treatment of titanium-based implants before any biological use.
机译：在具有不同表面粗糙度的Ti6Al4V钛合金样品上进行了小鼠（MC3T3-E1）成骨细胞和原代人成骨细胞的增殖和粘附。制备机械或手动抛光的表面以分别产生未取向或取向的残余抛光槽。使用500微米或3毫米氧化铝颗粒制备喷砂表面。与扩散和粘附参数相比，表面粗糙度参数显示出负相关。 X射线微探针化学表面显微分析表明，喷砂处理后的Ti6Al4V合金表面元素组成完全被破坏。在样品表面观察到AlOx富集层。这可能导致怀疑表面粗糙度幅度和AlOx表面浓度的伴随作用对成骨细胞的增殖和粘附有影响。这些发现表明，在对钛基植入物进行任何生物处理之前，对其进行任何表面处理后，化学表面分析的重要性。

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