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首页> 外文期刊>Biomaterials >Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation.
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Macroencapsulation of human cartilage implants: pilot study with polyelectrolyte complex membrane encapsulation.

机译：人软骨植入物的大囊包裹：聚电解质复合膜包裹的初步研究。

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摘要

Autogenous cartilage transplantation is a generally accepted method in reconstructive surgery. A promising alternative to this established method could be represented by in vitro engineering of cartilage tissue. In both methods of autogenous transplantation, host response induces reduction of transplant size and transplant instability to an unforeseeable extent. To investigate if polyelectrolyte complex (PEC) membranes were able to avoid host-induced effects on implanted tissues without neglecting the tissue metabolism, human septal cartilage was encapsulated with polyelectrolyte complex membranes and subcutaneously implanted on the back of nude mice. Septal cartilage implants, without encapsulation served as control group. Histochemical and electron microscopic investigations were performed 1, 4, 8 and 16 weeks after implantation. In the case of an intact PEC-membrane no interactions between the host and the implant could be observed. In some implants, the capsule was torn in several areas and signs of chronic inflammation with the cartilage having been affected mildly could be observed. Implanted cartilage protected with PEC-encapsulation showed no signs of degeneration and significantly lower level of after effects of chronic inflammation than implanted cartilage without PEC-encapsulation. Therefore, it could be expected, that PEC membrane encapsulation offers a novel approach to protect cartilage implants from host response after autogenous transplantation.
机译：自体软骨移植是重建手术中普遍接受的方法。软骨组织的体外工程学可以代表这种已建立方法的有希望的替代方法。在两种自体移植方法中，宿主反应都会在无法预料的范围内导致移植物尺寸减小和移植物不稳定。为了研究聚电解质复合物（PEC）膜是否能够避免宿主对植入组织的影响而不会忽略组织代谢，将人间隔软骨包裹有聚电解质复合物膜并皮下植入裸鼠的背部。将未包封的间隔软骨植入物作为对照组。植入后1、4、8和16周进行组织化学和电子显微镜检查。在完整的PEC膜的情况下，不能观察到宿主与植入物之间的相互作用。在某些植入物中，囊膜在多个区域被撕裂，可以观察到慢性炎症的迹象，软骨受到了轻微的影响。与没有PEC封装的植入软骨相比，受PEC封装保护的植入软骨没有出现退化的迹象，并且慢性炎症的后遗症水平明显降低。因此，可以预期的是，PEC膜包囊提供了一种保护自体移植后软骨植入物免受宿主反应的新方法。

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