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首页> 外文期刊>Biomaterials >Synthesis and properties of amphiphilic networks 3: preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)).
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Synthesis and properties of amphiphilic networks 3: preparation and characterization of block conetworks of poly(butyl methacrylate-block-(2,3 propandiol-1-methacrylate-stat-ethandiol dimethacrylate)).

机译：两亲性网络的合成和性质3：聚（甲基丙烯酸丁酯-嵌段-（（2,3丙二醇-1-甲基丙烯酸-stat-乙二醇二甲基丙烯酸酯））的嵌段共网络的制备和表征。

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Amphiphilic conetwork polymers were prepared and studied as substrates in the culture of dermal fibroblasts. Both block and random conetworks polymers were produced by radical polymerization of either low-molecular weight monomers or oligomeric macromonomers. The oligomeric macromonomers were prepared by methacrylation of biscarboxy oligo(butyl methacrylates) (OBMA). The latter were synthesized by ozononolysis of poly(butyl methacrylate-co-butadiene) materials. The hydrophilic component was derived from copolymerization with 2,3 propandiol-1-methacrylate and cross-linking was provided by inclusion of ethandiol dimethacrylate (EDMA). None of the synthesized materials showed indications of cytotoxicity to human dermal fibroblasts. All of the block conetworks were highly phase separated and possessed pores on the micron length scale. The equilibrium water contents of the latter could be controlled by addition of EDMA. Block conetworks that did not contain EDMA were highly swollen and had smoother surfacesthan those that contained EDMA. The former were poor substrates for cell proliferation (as measured by monitoring DNA content) whilst the latter class gave increasing levels of DNA during culture; an indicator proliferation. The performance of these materials in cell culture was also dependent on the fraction of OBMA in the formulation. Increasing the fractions of BMA, either in the random terpolymer or block networks, system had the effect of increasing both cell proliferation and viability (as measured by the Alamar Blue assay).
机译：制备两亲共网络聚合物，并将其作为真皮成纤维细胞培养物中的底物进行研究。嵌段和无规共网络聚合物均通过低分子量单体或低聚大分子单体的自由基聚合而制得。低聚大分子单体是通过双羧基低聚（甲基丙烯酸丁酯）（OBMA）的甲基化制备的。后者是通过臭氧分解聚（甲基丙烯酸丁酯-共丁二烯）材料而合成的。亲水性组分源自与2,3-丙二醇-1-甲基丙烯酸酯的共聚反应，并通过包含乙二醇二甲基丙烯酸酯（EDMA）提供交联。合成的材料均未显示出对人真皮成纤维细胞有细胞毒性的迹象。所有的嵌段共网络都是高度相分离的，并具有微米长度尺度的孔。后者的平衡水含量可以通过添加EDMA来控制。与不包含EDMA的块协同网络相比，其高度膨胀且表面更平滑。前者是细胞增殖的不良底物（通过监测DNA含量来衡量），而后者则在培养过程中增加了DNA的水平。指标扩散。这些材料在细胞培养中的性能还取决于制剂中OBMA的比例。在无规三元共聚物或嵌段网络中，增加BMA的比例，系统具有增加细胞增殖和生存力的作用（通过Alamar Blue分析测定）。

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