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首页> 外文期刊>Biomaterials >Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking
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Phosphorescent iridium(III) complexes as multicolor probes for specific mitochondrial imaging and tracking

机译：磷光铱（III）配合物作为多色探针，用于特异性线粒体成像和跟踪

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摘要

In the present study, four phosphorescent iridium(III) complexes [Ir(C-N)2(PhenSe)]+ (Ir1-Ir4, in which C-N=2-(2,4-difluorophenyl)pyridine (dfppy), dibenzo[f,h]quinoxaline (dbq), 2-phenylquinoline (2-pq) and 2-phenylpyridine (ppy), PhenSe=1,10-phenanthrolineselenazole) with tunable emission colors were developed to image mitochondria and track the dynamics of the mitochondrial morphology. In comparison with commercially available mitochondrial trackers, Ir1-Ir4 possess high specificity to mitochondria in live and fixed cells without requiring prior membrane permeabilization or the replacement of the culture medium. Due to the high resistance of Ir1-Ir4 to the loss of mitochondrial membrane potential as well as the appreciable tolerance to environmental changes, these complexes are applicable for the imaging and tracking of the mitochondrial morphological changes over long periods of time. In addition, Ir2-Ir4 exhibited superior photostability compared to the commercially available mitochondrial trackers. These colorful iridium(III) complexes may contribute to the future development of staining agents for organelle-selective imaging in living cells.
机译：在本研究中，四种磷光铱（III）络合物[Ir（CN）2（PhenSe）] +（Ir1-Ir4，其中CN = 2-（2,4-二氟苯基）吡啶（dfppy），二苯并[f， h]具有可调发射颜色的喹喔啉（dbq），2-苯基喹啉（2-pq）和2-苯基吡啶（ppy），PhenSe = 1,10-菲咯啉基硒唑）可以为线粒体成像并跟踪线粒体形态的动态变化。与市售的线粒体追踪剂相比，Ir1-Ir4对活细胞和固定细胞中的线粒体具有很高的特异性，而无需事先进行膜透化或更换培养基。由于Ir1-Ir4对线粒体膜电位的丧失具有很高的抵抗力，并且对环境变化具有明显的耐受性，因此这些配合物可用于长时间内对线粒体形态变化的成像和跟踪。此外，与市售的线粒体追踪剂相比，Ir2-Ir4具有更高的光稳定性。这些多彩的铱（III）配合物可能有助于将来在活细胞中进行细胞器选择性成像的染色剂的开发。

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